Ultrashort plasma cell-free DNA: a novel non-invasive maker for cancer diagnostics

被引：0
作者：
Zhao, Guodong [1 ]
机构：
[1] Kunshan Hosp Tradit Chinese Med, Dept Spleen & Stomach Dis, Kunshan 215300, Jiangsu, Peoples R China
来源：
AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2024年 / 13卷 / 04期
关键词：
uscfDNA; mncfDNA; plasma;
D O I：
10.62347/UQTM2281
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have shown that ultrashort plasma cell-free DNA (uscfDNA), a novel type of cfDNA fragment approximately 50 nucleotides long, differs from conventional monocyte-derived cfDNA in several aspects, including specific extraction requirements and a higher incidence of tumor-specific genetic alterations. uscfDNA shows promise in enhancing liquid biopsy sensitivity for cancer detection, with distinct methylation profiles observed in cancer patients. These findings suggest uscfDNA analysis could significantly improve non-invasive cancer diagnostics, offering new avenues for early detection and personalized medicine strategies.
引用
收藏
页码：202 / 203
页数：2
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