α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy

被引：2
|
作者：
Xu, Qianhui [1 ,2 ]
Wang, Huilan [3 ,4 ]
Yang, Ruonan [3 ,4 ]
Tao, Youqi [5 ]
Wang, Ziying [3 ,4 ]
Zhang, Shengnan [1 ]
Sun, Bo [6 ]
Li, Dan [5 ,7 ]
Lu, Boxun [3 ,4 ]
Liu, Cong [1 ,8 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Fudan Univ, Sch Life Sci, State Key Lab Med Neurobiol, New Cornerstone Sci Lab, Shanghai, Peoples R China
[4] Fudan Univ, MOE Frontiers Ctr Brain Sci, Sch Life Sci, New Cornerstone Sci Lab, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, BioX Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai, Peoples R China
[6] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
[7] Shanghai Jiao Tong Univ, Zhangjiang Inst Adv Study, Shanghai, Peoples R China
[8] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Chem Biol, Shanghai, Peoples R China
来源：
CELL RESEARCH | 2025年 / 35卷 / 01期
关键词：
D O I：
10.1038/s41422-024-01022-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：72 / 75
页数：4
相关论文
共 50 条
  • [41] NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
    Shrestha, Birendra Kumar
    Rasmussen, Mads Skytte
    Abudu, Yakubu Princely
    Bruun, Jack-Ansgar
    Larsen, Kenneth Bowitz
    Alemu, Endalkachew A.
    Sjottem, Eva
    Lamark, Trond
    Johansen, Terje
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (05) : 1240 - 1260
  • [42] TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells
    Cheng-Cheng Wang
    Hong Peng
    Zi Wang
    Jiao Yang
    Rong-Gui Hu
    Chuan-Yin Li
    Wu-Jun Geng
    Military Medical Research, 2023, 10 (04) : 559 - 562
  • [43] TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells
    Cheng-Cheng Wang
    Hong Peng
    Zi Wang
    Jiao Yang
    Rong-Gui Hu
    Chuan-Yin Li
    Wu-Jun Geng
    Military Medical Research, 9
  • [44] Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation
    Tessa Nelemans
    Ali Tas
    Nina L. de Beijer
    George M. C. Janssen
    Peter A. van Veelen
    Martijn J. van Hemert
    Marjolein Kikkert
    Virology Journal, 22 (1)
  • [45] Neutrophils use selective autophagy receptor Sqstm1/p62 to targetStaphylococcus aureusfor degradationin vivoin zebrafish
    Gibson, Josie F.
    Prajsnar, Tomasz K.
    Hill, Christopher J.
    Tooke, Amy K.
    Serba, Justyna J.
    Tonge, Rebecca D.
    Foster, Simon J.
    Grierson, Andrew J.
    Ingham, Philip W.
    Renshaw, Stephen A.
    Johnston, Simon A.
    AUTOPHAGY, 2021, 17 (06) : 1448 - 1457
  • [46] p62/SQSTM1, a Key Autophagy Mediator, Is Regulated in Pancreatitis Through mTOR-Mediated Pathways
    Pimienta, Michael
    Lotshaw, Ethan
    Elperin, Jason
    Malla, Sudarshan
    Ohmuraya, Masaki
    Mareninova, Olga
    Gukovskaya, Anna
    Gukovsky, Ilya
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 : S14 - S14
  • [47] Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression
    He, Jian-Ping
    Hou, Pei-Pei
    Chen, Qi-Tao
    Wang, Wei-Jia
    Sun, Xiao-Yu
    Yang, Peng-Bo
    Li, Ying-Ping
    Yao, Lu-Ming
    Li, Xiaotong
    Jiang, Xin-Dong
    Chien, Kun-Yi
    Zhang, Zhi-Ming
    Wu, Qiu-Wan
    Cowin, Allison J.
    Wu, Qiao
    Chen, Hang-Zi
    CANCER RESEARCH, 2018, 78 (17) : 4853 - 4864
  • [48] Autophagy-mediated upregulation of cytoplasmic claudin 1 stimulates the degradation of SQSTM1/p62 under starvation
    Kim, Jaewhan
    Choi, Sunkyung
    Kim, Jong Ok
    Kim, Kee K.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 496 (01) : 159 - 166
  • [49] Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy
    Park, Sungwoo
    Choi, Seon-Guk
    Yoo, Seung-Min
    Son, Jin H.
    Jung, Yong-Keun
    AUTOPHAGY, 2014, 10 (11) : 1906 - 1920
  • [50] Enhancing Efficacy of Albumin-Bound Paclitaxel for Human Lung and Colorectal Cancers through Autophagy Receptor Sequestosome 1 (SQSTM1)/p62-Mediated Nanodrug Delivery and Cancer therapy
    Lin, Yu-Wei
    Lin, Tzu-Ting
    Chen, Chien-Hung
    Wang, Rou-Hsin
    Lin, Ya-Hui
    Tseng, Tzu-Yen
    Zhuang, Yan-Jun
    Tang, Sheng-Yueh
    Lin, Yen-Cheng
    Pang, Jiun-Yu
    Chakravarthy, Rajan Deepan
    Lin, Hsin-Chieh
    Tzou, Shey-Cherng
    Chao, Jui-, I
    ACS NANO, 2023, 17 (19) : 19033 - 19051
12345