Fatal hyperpyrexia caused by xylazine: a case report

被引：1

作者：

Dai, Ping ^{[1
]}

Chen, Yanqing ^{[2
]}

Luo, Xianqin ^{[3
]}

Zhou, Zhiqiang ^{[1
,4
]}

Shi, Mengdi ^{[1
,4
]}

Genjiafu, Aerbusili ^{[1
,4
]}

Jian, Xiangdong ^{[1
,4
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Poisoning & Occupat Dis Emergency med, Cheeloo Coll Med, Jinan, Peoples R China

[2] Huangdao Dist Cent Hosp, Emergency Dept, Qingdao, Peoples R China

[3] Suining Cent Hosp, Emergency Dept, Suining, Peoples R China

[4] Shandong Univ, Cheeloo Coll Med, Sch Publ Hlth, Dept Occupat & Environm Hlth, Jinan, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

drugs; human; hyperpyrexia; poisoning; xylazine; SEVERE INTOXICATION; AGONISTS; ABUSE; DRUG;

D O I：

10.3389/fphar.2024.1437960

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Xylazine is used in veterinary medicine as a sedative, analgesic, and muscle relaxant. However, in recent decades, it has frequently been detected in illicit drugs. Xylazine poisoning is characterized by depression of the central nervous and cardiovascular systems. Herein, we present a case of a 41-year-old man who not only had severe depression of the central nervous and cardiovascular systems, but also developed hyperpyrexia during the treatment of xylazine poisoning, which led to his death 3 days after poisoning. This case indicates that, in addition to its other effects, xylazine may also cause hyperthermia, which has not yet been reported in humans.

引用

页数：5

共 20 条

[1] Xylazine poisoning: a systematic review
Ball, Noah S.
Knable, Brittany M.
Relich, Taylor A.
Smathers, Allyson N.
Gionfriddo, Michael R.
Nemecek, Branden D.
Montepara, Courtney A.
Guarascio, Anthony J.
Covvey, Jordan R.
Zimmerman, David E.
[J]. CLINICAL TOXICOLOGY, 2022, 60 (08) : 892 - 901
[2] Severe intoxication from xylazine inhalation
Capraro, AJ
Wiley, JF
Tucker, JR
[J]. PEDIATRIC EMERGENCY CARE, 2001, 17 (06) : 447 - 448
[3] Drug abuse with inhalated xylazine
Elejalde, Jose I.
Jean Louis, Clint
Elcuaz, Rosario
Pinillos, Miguel A.
[J]. EUROPEAN JOURNAL OF EMERGENCY MEDICINE, 2003, 10 (03) : 252 - 253
[4] Preoptic α1- and α2-noradrenergic agonists induce, respectively, PGE2-independent and PGE2-dependent hyperthermic responses in guinea pigs
Feleder, C
Perlik, V
Blatteis, CM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 286 (06) : R1156 - R1166
[5] Detection of Serum Interleukin-6/10/18 Levels in Sepsis and Its Clinical Significance
Feng, Mingchen
Sun, Tingting
Zhao, Yaxin
Zhang, Hui
[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2016, 30 (06) : 1037 - 1043
[6] FLAVAHAN NA, 1991, NEWS PHYSIOL SCI, V6, P251
[7] Xylazine - Medical and Public Health Imperatives
Gupta, Rahul
Holtgrave, David R.
Ashburn, Michael A.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388 (24) : 2209 - 2212
[8] Severe intoxication with the veterinary tranquilizer xylazine in humans
Hoffmann, U
Meister, CM
Golle, K
Zschiesche, M
[J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 2001, 25 (04) : 245 - 249
[9] CLINICAL PHARMACOLOGY OF XYLAZINE IN CATTLE
HOPKINS, TJ
[J]. AUSTRALIAN VETERINARY JOURNAL, 1972, 48 (03) : 109 - &
[10] Kaur Harleen, 2019, Mo Med, V116, P154

← 1 2 →