Artemisinin and Its Derivatives as Potential Anticancer Agents

被引：17
作者：
Wen, Luan [1 ,2 ]
Chan, Ben Chung-Lap [1 ,2 ]
Qiu, Ming-Hua [3 ]
Leung, Ping-Chung [1 ,2 ]
Wong, Chun-Kwok [1 ,2 ,4 ,5 ]
机构：
[1] Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, State Key Lab Res Bioact & Clin Applicat Med Plant, Hong Kong, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources Wes, Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
[4] Chinese Univ Hong Kong, Fac Med, Dept Chem Pathol, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Li Dak Sum Yip Yio Chin R&D Ctr Chinese Med, Hong Kong, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 16期
关键词：
artemisinin; dihydroartemisinin; artesunate; anticancer activity; CELL LUNG-CANCER; ADD-ON THERAPY; METASTATIC BREAST-CANCER; ORAL ARTESUNATE; PHASE-I; DIHYDROARTEMISININ; APOPTOSIS; MIGRATION; PROLIFERATION; INVASION;
D O I：
10.3390/molecules29163886
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Artemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb Artemisia annua L. (qinghao). Artemisinin and its derivatives share an unusual endoperoxide bridge and are extensively used for malaria treatment worldwide. In addition to antimalarial activities, artemisinin and its derivatives have been reported to exhibit promising anticancer effects in recent decades. In this review, we focused on the research progress of artemisinin and its derivatives with potential anticancer activities. The pharmacological effects, potential mechanisms, and clinical trials in cancer therapy of artemisinin and its derivatives were discussed. This review may facilitate the future exploration of artemisinin and its derivatives as effective anticancer agents.
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页数：20
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