Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

被引：8
|
作者：
Lin, Aifen [1 ,2 ]
Zhang, Rui-Li [2 ]
Zhang, Xia [1 ]
He, Xiao-Fang [3 ]
Zhang, Jian-Gang [1 ]
Yan, Wei-Hua [4 ]
机构：
[1] Wenzhou Med Univ, Biol Resource Ctr, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Dept Gastrointestinal Surg, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China
[3] Lanxi Peopless Hosp, Dept Lab Med, Lanxi, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Med Res Ctr, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2019年 / 23卷 / 02期
基金：
中国国家自然科学基金;
关键词：
colorectal cancer; diagnosis; MACC1; prognosis; COLON CANCER-1; HEPATOCELLULAR-CARCINOMA; METASTASIS; EXPRESSION;
D O I：
10.1111/jcmm.13989
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The clinical significance of metastasis-associated in colon cancer-1 (MACC1) has been investigated but the relevance of peripheral MACC1 levels was rather limited. Herein, our data revealed that plasma MACC1 levels in 117 colorectal cancer patients (CRC) were dramatically higher than that in normal controls (P < 0.001), and with a strong discrimination power between the two groups (AUC = 0.960, P < 0.001). Moreover, MACC1 is an independent prognostic factor for CRC patients. When clinical parameters stratified by MACC1(low) and MACC1(high), MACC1 levels exhibited further significant predictive value. Summary, plasma MACC1 levels could be a useful prognostic and diagnostic biomarker, and could improve the prognostic value of traditional prognosticators for colorectal cancer patients.
引用
收藏
页码：1598 / 1601
页数：4
相关论文
共 50 条
  • [21] MicroRNA-143 Targets MACC1 to Inhibit Cell Invasion and Migration in Colorectal cancer
    Zhang, Yu
    Wang, Zhongqiu
    Chen, Min
    Peng, Liang
    Wang, Xinying
    Ma, Qunying
    Ma, Fengli
    Jiang, Bo
    MOLECULAR CANCER, 2012, 11
  • [22] MACC1 and HGF are associated with survival in patients with gastric cancer
    Dong, Guokai
    Wang, Man
    Gu, Guangfu
    Li, Shanshan
    Sun, Xiaoming
    Li, Zhouru
    Cai, Hongxing
    Zhu, Zhengqiu
    ONCOLOGY LETTERS, 2018, 15 (03) : 3207 - 3213
  • [23] Prognostic and clinicopathological significance of MACC1 expression in hepatocellular carcinoma patients: a meta-analysis
    Sun, Da-Wei
    Zhang, Ying-Yi
    Qi, Yue
    Liu, Gui-Qi
    Chen, Yu-Guo
    Ma, Jian
    Lv, Guo-Yue
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (04): : 4769 - 4777
  • [24] Metastasis associated in colon cancer 1 (MACC1): at the crossroads of cancer metastasis and drug resistanced
    Guo, Tao
    Gu, Chundong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (10): : 10355 - 10363
  • [25] Significant survival impact of MACC1 polymorphisms in HER2 positive breast cancer patients
    Muendlein, Axel
    Hubalek, Michael
    Geller-Rhomberg, Simone
    Gasser, Klaus
    Winder, Thomas
    Drexel, Heinz
    Decker, Thomas
    Mueller-Holzner, Elisabeth
    Chamson, Martina
    Marth, Christian
    Lang, Alois H.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 (12) : 2134 - 2141
  • [26] MicroRNA target for MACC1 and CYR61 to inhibit tumor growth in mice with colorectal cancer
    Wang, Guiqi
    Gu, Jingfeng
    Gao, Yingchao
    TUMOR BIOLOGY, 2016, 37 (10) : 13983 - 13993
  • [27] MACC1 as a Potential Target for the Treatment and Prevention of Breast Cancer
    Lv, Mengmeng
    Jiao, Yunjuan
    Yang, Bowen
    Ye, Mengchen
    Di, Wenyu
    Su, Wei
    Zhong, Jiateng
    BIOLOGY-BASEL, 2023, 12 (03):
  • [28] Prognostic Significance of Serum Adipokine Levels in Colorectal Cancer Patients
    Guadagni, Fiorella
    Roselli, Mario
    Martini, Francesca
    Spila, Antonella
    Riondino, Silvia
    D'Alessandro, Roberta
    Del Monte, Girolamo
    Formica, Vincenzo
    Laudisi, Anastasia
    Portarena, Ilaria
    Palmirotta, Raffaele
    Ferroni, Patrizia
    ANTICANCER RESEARCH, 2009, 29 (08) : 3321 - 3327
  • [29] miR-338-3p suppresses colorectal cancer proliferation and progression by inhibiting MACC1
    Zou, Teng
    Duan, Jing
    Liang, Jiangtao
    Shi, Huijuan
    Zhen, Tiantian
    Li, Hui
    Zhang, Fenfen
    Dong, Yu
    Han, Anjia
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2018, 11 (04): : 2256 - 2267
  • [30] Overexpression of MACC1 and Its significance in human Breast Cancer Progression
    Yongbo Huang
    Huizhong Zhang
    Junchao Cai
    Lishan Fang
    Jueheng Wu
    Caisheng Ye
    Xun Zhu
    Mengfeng Li
    Cell & Bioscience, 3
12345