Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

被引：8
作者：
Lin, Aifen [1 ,2 ]
Zhang, Rui-Li [2 ]
Zhang, Xia [1 ]
He, Xiao-Fang [3 ]
Zhang, Jian-Gang [1 ]
Yan, Wei-Hua [4 ]
机构：
[1] Wenzhou Med Univ, Biol Resource Ctr, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Dept Gastrointestinal Surg, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China
[3] Lanxi Peopless Hosp, Dept Lab Med, Lanxi, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Med Res Ctr, Taizhou Hosp Zhejiang Prov, Linhai, Zhejiang, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2019年 / 23卷 / 02期
基金：
中国国家自然科学基金;
关键词：
colorectal cancer; diagnosis; MACC1; prognosis; COLON CANCER-1; HEPATOCELLULAR-CARCINOMA; METASTASIS; EXPRESSION;
D O I：
10.1111/jcmm.13989
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The clinical significance of metastasis-associated in colon cancer-1 (MACC1) has been investigated but the relevance of peripheral MACC1 levels was rather limited. Herein, our data revealed that plasma MACC1 levels in 117 colorectal cancer patients (CRC) were dramatically higher than that in normal controls (P < 0.001), and with a strong discrimination power between the two groups (AUC = 0.960, P < 0.001). Moreover, MACC1 is an independent prognostic factor for CRC patients. When clinical parameters stratified by MACC1(low) and MACC1(high), MACC1 levels exhibited further significant predictive value. Summary, plasma MACC1 levels could be a useful prognostic and diagnostic biomarker, and could improve the prognostic value of traditional prognosticators for colorectal cancer patients.
引用
收藏
页码：1598 / 1601
页数：4
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