Epigenetic Modifiers in Cancer Metastasis

被引:2
作者
Hu, Die [1 ,2 ,3 ]
Zhao, Tianci [4 ,5 ]
Xu, Chenxing [3 ]
Pan, Xinyi [3 ]
Zhou, Zhengyu [1 ,2 ,6 ]
Wang, Shengjie [1 ,2 ,3 ,6 ]
机构
[1] Nanjing Med Univ, Kangda Coll, Key Lab Mol Genet, Suzhou 215123, Peoples R China
[2] Soochow Univ, Suzhou Med Coll, Key Lab Mol Genet, Suzhou 215123, Peoples R China
[3] Nanjing Med Univ, Kangda Coll, Dept Basic Med, Lianyungang 222000, Peoples R China
[4] China Med Univ, Minist Publ Hlth, Key Lab Cell Biol, Shenyang 110122, Peoples R China
[5] China Med Univ, Minist Educ, Key Lab Med Cell Biol, Shenyang 110122, Peoples R China
[6] Soochow Univ, Suzhou Med Coll, Lab Anim Ctr, Suzhou 215123, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
epigenetics; DNA methylation; histone methylation; non-coding RNAs; metastasis; ENHANCER REPROGRAMMING PROMOTES; BREAST-CANCER; NONCODING RNA; LUNG METASTASIS; MESSENGER-RNA; LIVER-DISEASE; CELL; METHYLATION; GROWTH; CHROMATIN;
D O I
10.3390/biom14080916
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metastasis is the primary cause of cancer-related death, with the dissemination and colonization of primary tumor cells at the metastatic site facilitated by various molecules and complex pathways. Understanding the biological mechanisms underlying the metastatic process is critical for the development of effective interventions. Several epigenetic modifications have been identified that play critical roles in regulating cancer metastasis. This review aims to provide a comprehensive summary of recent advances in understanding the role of epigenetic modifiers, including histone modifications, DNA methylation, non-coding RNAs, enhancer reprogramming, chromatin accessibility, and N6-methyladenosine, in metastasis-associated processes, such as epithelial-mesenchymal transition (EMT), cancer cell migration, and invasion. In particular, this review provides a detailed and in-depth description of the role of crosstalk between epigenetic regulators in tumor metastasis. Additionally, we explored the potential and limitations of epigenetics-related target molecules in the diagnosis, treatment, and prognosis of cancer metastasis.
引用
收藏
页数:23
相关论文
共 177 条
  • [61] Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression
    Hu, Zonglong
    Wei, Fan
    Su, Yi
    Wang, Yafang
    Shen, Yanyan
    Fang, Yanfen
    Ding, Jian
    Chen, Yi
    [J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)
  • [62] Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis
    Huang, Xiu-Yan
    Huang, Zi-Li
    Huang, Jin
    Xu, Bin
    Huang, Xin-Yu
    Xu, Yong-Hua
    Zhou, Jian
    Tang, Zhao-You
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)
  • [63] TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma
    Itoh, Hitoshi
    Kadomatsu, Tsuyoshi
    Tanoue, Hironori
    Yugami, Masaki
    Miyata, Keishi
    Endo, Motoyoshi
    Morinaga, Jun
    Kobayashi, Eisuke
    Miyamoto, Takeshi
    Kurahashi, Ryoma
    Terada, Kazutoyo
    Mizuta, Hiroshi
    Oike, Yuichi
    [J]. ONCOGENE, 2018, 37 (22) : 2903 - 2920
  • [64] Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
    Janin, Maxime
    Davalos, Veronica
    Esteller, Manel
    [J]. CANCER AND METASTASIS REVIEWS, 2023, 42 (04) : 1071 - 1112
  • [65] MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer
    Ji, P
    Diederichs, S
    Wang, WB
    Böing, S
    Metzger, R
    Schneider, PM
    Tidow, N
    Brandt, B
    Buerger, H
    Bulk, E
    Thomas, M
    Berdel, WE
    Serve, H
    Müller-Tidow, C
    [J]. ONCOGENE, 2003, 22 (39) : 8031 - 8041
  • [66] Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer
    Jia, Yongxu
    Yan, Qian
    Zheng, Yinli
    Li, Lei
    Zhang, Baifeng
    Chang, Zhiwei
    Wang, Zehua
    Tang, Hong
    Qin, Yanru
    Guan, Xin-Yuan
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2022, 41 (01)
  • [67] Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis
    Jiang, Hao
    Cao, Hui-Jun
    Ma, Ning
    Bao, Wen-Dai
    Wang, Jing-Jing
    Chen, Tian-Wei
    Zhang, Er-Bin
    Yuan, Yan-Mei
    Ni, Qian-Zhi
    Zhang, Feng-Kun
    Ding, Xu-Fen
    Zheng, Qian-Wen
    Wang, Yi-Kang
    Zhu, Min
    Wang, Xiang
    Feng, Jing
    Zhang, Xue-Li
    Cheng, Shu-Qun
    Ma, Dan-Jun
    Qiu, Lin
    Li, Jing-Jing
    Xie, Dong
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (09) : 4770 - 4780
  • [68] The role of E3 ubiquitin ligase HECTD3 in cancer and beyond
    Jiang, Qiuyun
    Li, Fubing
    Cheng, Zhuo
    Kong, Yanjie
    Chen, Ceshi
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2020, 77 (08) : 1483 - 1495
  • [69] KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma
    Jiang, Yuhang
    Li, Fengfeng
    Gao, Bowen
    Ma, Mengjun
    Chen, Meng
    Wu, Yanfeng
    Zhang, Weidong
    Sun, Yangbai
    Liu, Sanhong
    Shen, Huiyong
    [J]. THERANOSTICS, 2021, 11 (08): : 3868 - 3881
  • [70] Johansson C, 2016, NAT CHEM BIOL, V12, P539, DOI [10.1038/nchembio.2087, 10.1038/NCHEMBIO.2087]