Epigenetic Modifiers in Cancer Metastasis

被引:2
作者
Hu, Die [1 ,2 ,3 ]
Zhao, Tianci [4 ,5 ]
Xu, Chenxing [3 ]
Pan, Xinyi [3 ]
Zhou, Zhengyu [1 ,2 ,6 ]
Wang, Shengjie [1 ,2 ,3 ,6 ]
机构
[1] Nanjing Med Univ, Kangda Coll, Key Lab Mol Genet, Suzhou 215123, Peoples R China
[2] Soochow Univ, Suzhou Med Coll, Key Lab Mol Genet, Suzhou 215123, Peoples R China
[3] Nanjing Med Univ, Kangda Coll, Dept Basic Med, Lianyungang 222000, Peoples R China
[4] China Med Univ, Minist Publ Hlth, Key Lab Cell Biol, Shenyang 110122, Peoples R China
[5] China Med Univ, Minist Educ, Key Lab Med Cell Biol, Shenyang 110122, Peoples R China
[6] Soochow Univ, Suzhou Med Coll, Lab Anim Ctr, Suzhou 215123, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
epigenetics; DNA methylation; histone methylation; non-coding RNAs; metastasis; ENHANCER REPROGRAMMING PROMOTES; BREAST-CANCER; NONCODING RNA; LUNG METASTASIS; MESSENGER-RNA; LIVER-DISEASE; CELL; METHYLATION; GROWTH; CHROMATIN;
D O I
10.3390/biom14080916
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metastasis is the primary cause of cancer-related death, with the dissemination and colonization of primary tumor cells at the metastatic site facilitated by various molecules and complex pathways. Understanding the biological mechanisms underlying the metastatic process is critical for the development of effective interventions. Several epigenetic modifications have been identified that play critical roles in regulating cancer metastasis. This review aims to provide a comprehensive summary of recent advances in understanding the role of epigenetic modifiers, including histone modifications, DNA methylation, non-coding RNAs, enhancer reprogramming, chromatin accessibility, and N6-methyladenosine, in metastasis-associated processes, such as epithelial-mesenchymal transition (EMT), cancer cell migration, and invasion. In particular, this review provides a detailed and in-depth description of the role of crosstalk between epigenetic regulators in tumor metastasis. Additionally, we explored the potential and limitations of epigenetics-related target molecules in the diagnosis, treatment, and prognosis of cancer metastasis.
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页数:23
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共 177 条
  • [1] Brain metastases
    Achrol, Achal Singh
    Rennert, Robert C.
    Anders, Carey
    Soffietti, Riccardo
    Ahluwalia, Manmeet S.
    Nayak, Lakshmi
    Peters, Solange
    Arvold, Nils D.
    Harsh, Griffith R.
    Steeg, Patricia S.
    Chang, Steven D.
    [J]. NATURE REVIEWS DISEASE PRIMERS, 2019, 5 (1)
  • [2] The Inescapable Influence of Noncoding RNAs in Cancer
    Adams, Brian D.
    Anastasiadou, Eleni
    Esteller, Manel
    He, Lin
    Slack, Frank J.
    [J]. CANCER RESEARCH, 2015, 75 (24) : 5206 - 5210
  • [3] Nucleosidic DNA demethylating epigenetic drugs - A comprehensive review from discovery to clinic
    Agrawal, Khushboo
    Das, Viswanath
    Vyas, Pankhuri
    Hajduch, Marian
    [J]. PHARMACOLOGY & THERAPEUTICS, 2018, 188 : 45 - 79
  • [4] Epigenetic Therapeutics: A New Weapon in the War Against Cancer
    Ahuja, Nita
    Sharma, Anup R.
    Baylin, Stephen B.
    [J]. ANNUAL REVIEW OF MEDICINE, VOL 67, 2016, 67 : 73 - 89
  • [5] The role of m6A RNA methylation in cancer metabolism
    An, Yuanyuan
    Duan, Hua
    [J]. MOLECULAR CANCER, 2022, 21 (01)
  • [6] Non-coding RNA networks in cancer
    Anastasiadou, Eleni
    Jacob, Leni S.
    Slack, Frank J.
    [J]. NATURE REVIEWS CANCER, 2018, 18 (01) : 5 - 18
  • [7] Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis
    Azevedo, Hatylas
    Pessoa, Guilherme Cavalcante
    de Luna Vitorino, Francisca Nathalia
    Nsengimana, Jeremie
    Newton-Bishop, Julia
    Reis, Eduardo Moraes
    da Cunha, Julia Pinheiro Chagas
    Jasiulionis, Miriam Galvonas
    [J]. CLINICAL EPIGENETICS, 2020, 12 (01)
  • [8] CHD5 is a tumor suppressor at human 1p36
    Bagchi, Anindya
    Papazoglu, Cristian
    Wu, Ying
    Capurso, Daniel
    Brodt, Michael
    Francis, Dailia
    Bredel, Markus
    Vogel, Hannes
    Mills, Alea A.
    [J]. CELL, 2007, 128 (03) : 459 - 475
  • [9] Genomic analyses identify molecular subtypes of pancreatic cancer
    Bailey, Peter
    Chang, David K.
    Nones, Katia
    Johns, Amber L.
    Patch, Ann-Marie
    Gingras, Marie-Claude
    Miller, David K.
    Christ, Angelika N.
    Bruxner, Tim J. C.
    Quinn, Michael C.
    Nourse, Craig
    Murtaugh, L. Charles
    Harliwong, Ivon
    Idrisoglu, Senel
    Manning, Suzanne
    Nourbakhsh, Ehsan
    Wani, Shivangi
    Fink, Lynn
    Holmes, Oliver
    Chin, Vencssa
    Anderson, Matthew J.
    Kazakoff, Stephen
    Leonard, Conrad
    Newell, Felicity
    Waddell, Nick
    Wood, Scott
    Xu, Qinying
    Wilson, Peter J.
    Cloonan, Nicole
    Kassahn, Karin S.
    Taylor, Darrin
    Quek, Kelly
    Robertson, Alan
    Pantano, Lorena
    Mincarelli, Laura
    Sanchez, Luis N.
    Evers, Lisa
    Wu, Jianmin
    Pinese, Mark
    Cowley, Mark J.
    Jones, Marc D.
    Colvin, Emily K.
    Nagrial, Adnan M.
    Humphrey, Emily S.
    Chantrill, Lorraine A.
    Mawson, Amanda
    Humphris, Jeremy
    Chou, Angela
    Pajic, Marina
    Scarlett, Christopher J.
    [J]. NATURE, 2016, 531 (7592) : 47 - +
  • [10] EMT, MET, Plasticity, and Tumor Metastasis
    Bakir, Basil
    Chiarella, Anna M.
    Pitarresi, Jason R.
    Rustgi, Anil K.
    [J]. TRENDS IN CELL BIOLOGY, 2020, 30 (10) : 764 - 776