Insomnia symptoms as long-term predictors of anxiety symptoms in middle-aged and older adults from the English Longitudinal Study of Ageing (ELSA), and the role of systemic inflammation

被引:2
作者
Zagaria, Andrea [1 ]
Ballesio, Andrea [1 ]
机构
[1] Sapienza Univ Rome, Dept Psychol, Rome, Italy
关键词
Inflammation; C -reactive protein; CRP; Anxiety; Insomnia; Sleep problems; C-REACTIVE PROTEIN; SLEEP DISTURBANCE; IMMUNE-RESPONSE; DEPRESSION; DISORDERS; METAANALYSIS; ASSOCIATION; VARIABILITY; PREVALENCE; SEVERITY;
D O I
10.1016/j.sleep.2024.09.020
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Insomnia, i.e., difficulties in sleep onset and sleep maintenance, may increase the risk of anxiety symptoms, although long-term follow-up studies are rarely reported. Here, we examined whether insomnia symptoms may predict anxiety symptoms in a 9-year follow-up, and whether inflammation may play a mediating role. Data from 1355 participants (63.44 +/- 7.47 years, 55.1 % females) from the English Longitudinal Study of Ageing (ELSA) were analysed. Insomnia symptoms were assessed in 2012/13. High-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, was measured in 2016/17. Anxiety symptoms were assessed in 2020/21. After adjusting for confounders and baseline levels, structural equation modelling (SEM) revealed that insomnia symptoms significantly predicted anxiety symptoms (beta = 0.357, p < .001) but not hs-CRP (beta = -0.016, p = .634). Similarly, hs-CRP was not related to anxiety symptoms (beta = -0.024, p = .453). The hs-CRP mediation hypothesis was therefore rejected (beta = 0.0004; 95 % BCI -0.001 to 0.005), and multi-group SEM showed that sex did not moderate these paths. However, baseline diagnoses of anxiety disorders prospectively predicted higher hs-CRP (B = 0.083, p = .030). Results of the current study suggest that individuals with baseline anxiety disorders may be at higher risk of developing low-grade chronic inflammation. Several alternative psychophysiological mechanisms linking insomnia and anxiety symptoms should be explored, including autonomic and cortical pre-sleep arousal, cortisol reactivity, and pro-inflammatory cytokines. Finally, insomnia symptoms may be a treatment target to lower the risk of anxiety symptoms in elderly.
引用
收藏
页码:120 / 126
页数:7
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