Viral replication organelles: the highly complex and programmed replication machinery

被引:0
作者
Deng, Hao [1 ]
Cao, Hongwei [1 ]
Wang, Yanjin [1 ]
Li, Jiaqi [1 ]
Dai, Jingwen [1 ]
Li, Lian-Feng [1 ]
Qiu, Hua-Ji [1 ]
Li, Su [1 ]
机构
[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, Natl African Swine Fever Para reference Lab, Natl High Containment Facil Anim Dis Control & Pre, Harbin, Peoples R China
关键词
viral replication organelles; viral helicase; DNA sliding clamp; viral DNA ligase; viral polymerase; antiviral drugs; DEPENDENT RNA-POLYMERASE; PROCESSIVITY FACTOR; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; ANTIVIRAL ACTIVITY; ESCHERICHIA-COLI; DNA-REPLICATION; ACTIVE-SITE; EBOLA-VIRUS; HELICASE;
D O I
10.3389/fmicb.2024.1450060
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Viral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication. Within the ROs, viral replicases, including polymerases, helicases, and ligases, play functional roles during viral replication. These viral replicases are pivotal in the virus life cycle, and numerous studies have demonstrated that the viral replicases could be the potential targets for drugs development. Here, we summarize primarily the key replicases within viral ROs and emphasize the advancements of antiviral drugs targeting crucial viral replicases, providing novel insights into the future development of antiviral strategies.
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页数:15
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