Long-wavelength triggered iridium(III) complex nanoparticles for photodynamic therapy against hypoxic cancer

被引：7

作者：

Liu, Shengnan ^{[1
]}

Wang, Ziwei ^{[1
]}

Wu, Zihan ^{[1
]}

Chen, Haoran ^{[2
]}

Zhu, Dongxia ^{[1
]}

Li, Gungzhe ^{[3
]}

Yan, Mingming ^{[3
]}

Bryce, Martin R. ^{[4
]}

Chang, Yulei ^{[2
]}

机构：

[1] Northeast Normal Univ, Univ Jilin Prov, Dept Chem, Key Lab Nanobiosensing & Nanobioanalysis, 5268 Renmin St, Changchun 130024, Jilin, Peoples R China

[2] Chinese Acad Sci, State Key Lab Luminescence & Applicat, Changchun Inst Opt Fine Mech & Phys, Changchun 130033, Jilin, Peoples R China

[3] Changchun Univ Chinese Med, Jilin Prov Sci & Technol Innovat Ctr Hlth Food Chi, Changchun 130117, Jilin, Peoples R China

[4] Univ Durham, Dept Chem, Durham DH1 3LE, England

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 73期

基金：

中国博士后科学基金; 英国工程与自然科学研究理事会;

关键词：

HYPERBARIC-OXYGEN; MECHANISMS;

D O I：

10.1039/d4cc03501a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A long-wavelength triggered cationic iridium(III) complex, Ir5, and its corresponding nanoparticles with the ability to generate type I and type II reactive oxygen species have been synthesised. The complex targets mitochondria and achieves an excellent photodynamic therapy effect in hypoxic cancer cells.

引用

收藏

页码：9938 / 9941

页数：4

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