Asymmetric anti-Mannich reactions in continuous flow

被引：57
作者：
Martin-Rapun, Rafael [1 ]
Sayalero, Sonia [1 ]
Pericas, Miquel A. [1 ,2 ]
机构：
[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain
[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain
来源：
GREEN CHEMISTRY | 2013年 / 15卷 / 12期
关键词：
SOLID-SUPPORTED ORGANOCATALYST; CHIRAL AMINO SULFONAMIDE; N-BOC; 1,3-DIPOLAR CYCLOADDITIONS; ENANTIOSELECTIVE SYNTHESIS; GENERAL ORGANOCATALYST; ALPHA-AMINOXYLATION; ALDEHYDES; ACID; DERIVATIVES;
D O I：
10.1039/c3gc41444b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A polystyrene-supported, pyrrolidine-based catalyst depicting very high activity and excellent stereoselectivity in the anti-Mannich reaction of aldehydes and ketones has been developed. The very robust, immobilized catalyst has been successfully used in the implementation of a continuous flow process with short residence times (down to 6 min) for the production of highly enantioenriched anti-type Mannich adducts at the preparative scale.
引用
收藏
页码：3295 / 3301
页数：7
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