Progress of Exosomal LncRNAs in Pancreatic Cancer

被引:0
作者
Wei, Chengyan [1 ]
Zhang, Chunwei [1 ]
Zhou, Yuanzhi [1 ]
Wang, Jingjing [1 ]
Jin, Yong [1 ]
机构
[1] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
关键词
exosomes; LncRNA; exosomal LncRNAs; pancreatic cance; functions; LONG NONCODING RNA; EXTRACELLULAR VESICLES; MEDIATED METASTASIS; CHEMORESISTANCE; GLYCOSYLATION; EPIDEMIOLOGY; SECRETION; DIAGNOSIS; PROMOTE; GROWTH;
D O I
10.3390/ijms25168665
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pancreatic cancer is a prevalent malignant tumor with rising medication resistance and mortality. Due to a dearth of specific and trustworthy biomarkers and therapeutic targets, pancreatic cancer early detection and treatment are still not at their best. Exosomal LncRNAs have been found to be plentiful and persistent within exosomes, and they are capable of functioning whether the exosomes are traveling to close or distant cells. Furthermore, increasing evidence suggests that exosomal LncRNA, identified as an oncogene or tumor suppressor-control the growth, metastasis, and susceptibility of pancreatic cancer to chemotherapy and radiation therapy. Promising prospects for both antitumor targets and diagnostic biomarkers are exosomal LncRNAs. The primary features of exosomal LncRNAs, their biological roles in the onset and progression of pancreatic cancer, and their potential as therapeutic targets and diagnostic molecular markers are outlined in this review.
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页数:15
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