Genetically Proxied IL-6 Receptor Inhibition and Coronary Artery Disease Risk in a Japanese Population

被引：1

作者：

Zhao, Sizheng Steven ^{[1
]}

Gill, Dipender ^{[2
]}

机构：

[1] Univ Manchester, Fac Biol Med & Hlth, Ctr Musculoskeletal Res, Manchester Acad Hlth Sci Ctr,Div Musculoskeletal &, Oxford Rd, Manchester M13 9LJ, England

[2] Imperial Coll London, Dept Epidemiol & Biostat, London, England

来源：

CLINICAL THERAPEUTICS | 2024年 / 46卷 / 08期

关键词：

Coronary artery disease; Human genetics; IL-6; receptor; Mendelian randomization; Tocilizumab;

D O I：

10.1016/j.clinthera.2024.04.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：657 / 658

页数：2

共 7 条

[1] Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases [J].

Ferreira, Ricardo C. ;

Freitag, Daniel F. ;

Cutler, Antony J. ;

Howson, Joanna M. M. ;

Rainbow, Daniel B. ;

Smyth, Deborah J. ;

Kaptoge, Stephen ;

Clarke, Pamela ;

Boreham, Charlotte ;

Coulson, Richard M. ;

Pekalski, Marcin L. ;

Chen, Wei-Min ;

Onengut-Gumuscu, Suna ;

Rich, Stephen S. ;

Butterworth, Adam S. ;

Malarstig, Anders ;

Danesh, John ;

Todd, John A. .

PLOS GENETICS, 2013, 9 (04)

[2] Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics [J].

Giambartolomei, Claudia ;

Vukcevic, Damjan ;

Schadt, Eric E. ;

Franke, Lude ;

Hingorani, Aroon D. ;

Wallace, Chris ;

Plagnol, Vincent .

PLOS GENETICS, 2014, 10 (05)

[3] Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial [J].

Giles, Jon T. ;

Sattar, Naveed ;

Gabriel, Sherine ;

Ridker, Paul M. ;

Gay, Steffen ;

Warne, Charles ;

Musselman, David ;

Brockwell, Laura ;

Shittu, Emma ;

Klearman, Micki ;

Fleming, Thomas R. .

ARTHRITIS & RHEUMATOLOGY, 2020, 72 (01) :31-40

[4]

Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, 2012, Lancet, V379, P1214, DOI [10.1016/S0140-6736(12)60110-X, DOI 10.1016/S0140-6736(12)60110-X]

[5] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases [J].

Ishigaki, Kazuyoshi ;

Akiyama, Masato ;

Kanai, Masahiro ;

Takahashi, Atsushi ;

Kawakami, Eiryo ;

Sugishita, Hiroki ;

Sakaue, Saori ;

Matoba, Nana ;

Low, Siew-Kee ;

Okada, Yukinori ;

Terao, Chikashi ;

Amariuta, Tiffany ;

Gazal, Steven ;

Kochi, Yuta ;

Horikoshi, Momoko ;

Suzuki, Ken ;

Ito, Kaoru ;

Koyama, Satoshi ;

Ozaki, Kouichi ;

Niida, Shumpei ;

Sakata, Yasushi ;

Sakata, Yasuhiko ;

Kohno, Takashi ;

Shiraishi, Kouya ;

Momozawa, Yukihide ;

Hirata, Makoto ;

Matsuda, Koichi ;

Ikeda, Masashi ;

Iwata, Nakao ;

Ikegawa, Shiro ;

Kou, Ikuyo ;

Tanaka, Toshihiro ;

Nakagawa, Hidewaki ;

Suzuki, Akari ;

Hirota, Tomomitsu ;

Tamari, Mayumi ;

Chayama, Kazuaki ;

Miki, Daiki ;

Mori, Masaki ;

Nagayama, Satoshi ;

Daigo, Yataro ;

Miki, Yoshio ;

Katagiri, Toyomasa ;

Ogawa, Osamu ;

Obara, Wataru ;

Ito, Hidemi ;

Yoshida, Teruhiko ;

Imoto, Issei ;

Takahashi, Takashi ;

Tanikawa, Chizu .

NATURE GENETICS, 2020, 52 (07) :669-+

[6] IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial [J].

Ridker, Paul M. ;

Devalaraja, Matt ;

Baeres, Florian M. M. ;

Engelmann, Mads D. M. ;

Hovingh, G. Kees ;

Ivkovic, Milana ;

Lo, Larry ;

Kling, Douglas ;

Pergola, Pablo ;

Raj, Dominic ;

Libby, Peter ;

Davidson, Michael .

LANCET, 2021, 397 (10289) :2060-2069

[7] Distribution of serum C-reactive protein and its association with atherosclerotic risk factors in a Japanese population - Jichi Medical School Cohort Study [J].

Yamada, S ;

Gotoh, T ;

Nakashima, Y ;

Kayaba, K ;

Ishikawa, S ;

Nago, N ;

Nakamura, Y ;

Itoh, Y ;

Kajii, E .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2001, 153 (12) :1183-1190

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