Structure, function and evolution of the HerA subfamily proteins

被引：0

作者：

Sun, Yiyang ^{[2
]}

Cheng, Kaiying ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Peoples R China

[2] Hangzhou Normal Univ, Affiliated Hosp, Sch Basic Med Sci, Dept Immunol & Pathogen Biol,Zhejiang Key Lab Med, Hangzhou 311121, Peoples R China

来源：

DNA REPAIR | 2024年 / 142卷

关键词：

HerA; ATPase; DNA repair; Helicase; Nuclease; Anti-phage defense; CRISPR-CAS SYSTEMS; NURA; RESECTION; COMPLEX; REPAIR; MRE11; RAD50; FTSK; GENE;

D O I：

10.1016/j.dnarep.2024.103760

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

HerA is an ATP-dependent translocase that is widely distributed in archaea and some bacteria. It belongs to the HerA/FtsK translocase bacterial family, which is a subdivision of the RecA family. Currently, it is identified that HerA participates in the repair of DNA double-strand breaks (DSBs) or confers anti-phage defense by assembling other proteins into large complexes. In recent years, there has been a growing understanding of the bioinformatics, biochemistry, structure, and function of HerA subfamily members in both archaea and bacteria. This comprehensive review compares the structural disparities among diverse HerAs and elucidates their respective roles in specific life processes.

引用

页数：11

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