SARS-CoV-2 infections before, during, and after the Omicron wave: a 2-year Indian community cohort study

被引：2

作者：

Madhavan, Ramya ^{[1
]}

Paul, Jackwin Sam ^{[2
]}

Babji, Sudhir ^{[1
]}

Thamizh, Isai ^{[2
]}

Kumar, Dilesh ^{[2
]}

Khakha, Shainey Alokit ^{[1
]}

Rennie, Aarene ^{[1
]}

Kumar, Keerthana ^{[1
]}

Dhanapal, Pavithra ^{[1
]}

Saravanan, Poornima ^{[1
]}

Kumar, Ajith ^{[1
]}

Immanuel, Sushil ^{[1
]}

Gandhi, Vaishnavi ^{[1
]}

Kumar, Anand ^{[1
]}

Babu, Johnson John ^{[1
]}

Gangadharan, Nandu Thrithamarassery ^{[3
]}

Jagadeesan, Premkumar ^{[3
]}

John, Elizabeth ^{[3
]}

Jamora, Colin ^{[3
]}

Palakodeti, Dasaradhi ^{[3
]}

Bhati, Rubina ^{[3
]}

Thambidurai, Saranya Devi ^{[3
]}

Suvatha, Arati ^{[3
]}

George, Anna ^{[1
]}

Kang, Gagandeep ^{[1
]}

John, Jacob ^{[2
]}

机构：

[1] Christian Med Coll & Hosp, Wellcome Trust Res Lab, Vellore, India

[2] Christian Med Coll & Hosp, Dept Community Hlth, Vellore, India

[3] Inst Stem Cell Sci & Regenerat Med inStem, COVID 19 Testing & INSACOG Sequencing Lab, Bangalore, India

来源：

LANCET REGIONAL HEALTH - SOUTHEAST ASIA | 2024年 / 28卷

关键词：

SARS-CoV-2; Community cohort; Re-infections; Omicron; Surveillance strategies; VACCINATION; PROTECTION;

D O I：

10.1016/j.lansea.2024.100470

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background We measured the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and re-infections in an adult community-based cohort in southern India. Methods We conducted a 2-year follow-up on 1229 participants enrolled between May and October 2021. Participants provided vaccination histories, weekly saliva samples, and blood samples at 0, 6, 12, and 24 months. Salivary reverse transcription polymerase chain reaction (RT-PCR) and Meso-Scale Discovery panels were used for SARS-CoV-2 detection and anti-spike, anti-nucleocapsid immunoglobulin G quantification. fi cation. Whole genome sequencing was performed on a subset of positive samples. SARS-CoV-2 infection incidence was measured across Pre-Omicron (May-December - December 2021), Omicron-I (December 2021-June - June 2022), and Omicron-II (July 2022-October - October 2023) periods. Findings In total, 1166 (95%) participants with 83% seropositivity at baseline completed the follow-up, providing 2205 person-years of observation. Utilizing both RT-PCR and serology we identified fi ed 1306 infections and yielded an incidence rate of 591.3 per 1000 person-years (95% confidence fi dence interval, 559.6-624.3), - 624.3), which peaked during Omicron-I at 1418.1 per 1000 person-years (95% confidence fi dence interval, 1307.4-1535.6). - 1535.6). During Omicron-I and II, neither prior infection nor vaccination conferred protection against infection. Overall, 74% of infections were asymptomatic. Interpretation Integrated RT-PCR and serology revealed significant fi cant SARS-CoV-2 infection frequency, highlighting the prevalence of asymptomatic cases among previously infected or vaccinated individuals. This underscores the effectiveness of combining surveillance strategies when monitoring pandemic trends and confirms fi rms the role of non-invasive sampling in ensuring participant compliance, reflecting fl ecting national transmission patterns. Health Asia Published https://doi.org/10. 1016/j.lansea.2024. 100470

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