Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities

被引：7

作者：

Pick, Robert ^{[1
]}

Wang, Chen ^{[1
]}

Zeng, Qun ^{[1
]}

Gul, Zeynep Melis ^{[1
]}

Scheiermann, Christoph ^{[1
,2
,3
,4
]}

机构：

[1] Univ Geneva, Dept Pathol & Immunol, Fac Med, Geneva, Switzerland

[2] Geneva Ctr Inflammat Res GCIR, Geneva, Switzerland

[3] Translat Res Ctr Oncohaematol CRTOH, Geneva, Switzerland

[4] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Physiol & Pathophysiol, Biomed Ctr, Walter Brendel Ctr Expt Med,Fac Med, Planegg Martinsried, Germany

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2024年 / 42卷

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

circadian rhythms; immune system; cancer; immunotherapy; chrono-immunotherapy; REV-ERB-ALPHA; METASTATIC COLORECTAL-CANCER; CELL LUNG-CANCER; CLOCK PROTEINS; TIME; CHEMOTHERAPY; TRIAL; CHRONOTHERAPY; HOMEOSTASIS; COMPONENT;

D O I：

10.1146/annurev-immunol-090122-050842

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Circadian rhythms of approximately 24 h have emerged as important modulators of the immune system. These oscillations are important for mounting short-term, innate immune responses, but surprisingly also long-term, adaptive immune responses. Recent data indicate that they play a central role in antitumor immunity, in both mice and humans. In this review, we discuss the evolving literature on circadian antitumor immune responses and the underlying mechanisms that control them. We further provide an overview of circadian treatment regimens-chrono-immunotherapies-that harness time-of-day differences in immunity for optimal efficacy. Our aim is to provide an overview for researchers and clinicians alike, for a better understanding of the circadian immune system and how to best harness it for chronotherapeutic interventions. This knowledge is important for a better understanding of immune responses per se and could revolutionize the way we approach the treatment of cancer and a range of other diseases, ultimately improving clinical practice.

引用

页码：83 / 102

页数：20

共 107 条

[81] Circadian Rhythm Disruption Increases Tumor Growth Rate and Accumulation of Myeloid-Derived Suppressor Cells [J].