Routes and molecular mechanisms of central nervous system involvement in acute myeloid leukemia (Review)

被引：2

作者：

Chen, Liucui ^{[1
]}

Zeng, Piaorong ^{[2
]}

Tang, Huifang ^{[3
,4
,5
,6
]}

Chen, Gang ^{[7
]}

Xie, Juan ^{[1
]}

Yang, Xiaoyan ^{[1
]}

Lei, Xiaoyong ^{[1
,8
]}

机构：

[1] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, 28 Changshengxi Rd, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hematol, Hengyang 421001, Hunan, Peoples R China

[3] Univ South China, Hunan Prov Key Lab Multiom & Artificial Intelligen, Hengyang 421001, Hunan, Peoples R China

[4] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China

[5] Clin Res Ctr Myocardial Injury Hunan, Hengyang 421001, Hunan, Peoples R China

[6] Univ South China, Affiliated Hosp 1, Inst Cardiovasc Dis, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China

[7] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China

[8] Univ South China, Prov Key Lab Tumor Microenvironm Respons Drug Res, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China

来源：

ONCOLOGY REPORTS | 2024年 / 52卷 / 05期

关键词：

AML; CNS; cell adhesion molecules; brain barrier; therapeutic strategies; MATRIX-METALLOPROTEINASE INHIBITORS; BONE-MARROW SINUS; TRANSENDOTHELIAL MIGRATION; CD34(+) CELLS; ENDOTHELIAL DYSFUNCTION; ADHESION MOLECULES; PLATELET RECOVERY; EXPRESSION; PECAM-1; EGRESS;

D O I：

10.3892/or.2024.8805

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is a predominant form of leukemia. Central nervous system (CNS) involvement complicates its diagnosis due to limited diagnostic tools, as well as its treatment due to inadequate therapeutic methodologies and poor prognosis. Furthermore, its incidence rate is unclear. The mechanisms of AML cell mobilization from the bone marrow (BM) to the CNS are not fully elucidated, and the molecular factors contributing to CNS infiltration are insufficiently recognized. The present review aimed to enhance the understanding of CNS involvement of AML and its impact on CNS. The latest research on the pathways and mechanisms facilitating AML cells to escape the BM and infiltrate the CNS was reviewed. Additionally, novel therapeutic strategies targeting specific molecules and genes for treating CNS involvement in AML were examined.

引用

页数：11

共 111 条

[1] Symptomatic central nervous system involvement in adult patients with acute myeloid leukemia [J].

Alakel, Nael ;

Stoelzel, Friedrich ;

Mohr, Brigitte ;

Kramer, Michael ;

Oelschlaegel, Uta ;

Roellig, Christoph ;

Bornhaeuser, Martin ;

Ehninger, Gerhard ;

Schaich, Markus .

CANCER MANAGEMENT AND RESEARCH, 2017, 9 :97-102

[2] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[3] A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules [J].

Aspelund, Aleksanteri ;

Antila, Salli ;

Proulx, Steven T. ;

Karlsen, Tine Veronica ;

Karaman, Sinem ;

Detmar, Michael ;

Wiig, Helge ;

Alitalo, Kari .

JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (07) :991-999

[4]

AZZARELLI B, 1977, ARCH PATHOL LAB MED, V101, P203

[5] Electrostatic anti-CD33-antibody-protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia [J].

Baeumer, Nicole ;

Scheller, Annika ;

Wittmann, Lisa ;

Faust, Andreas ;

Apel, Mara ;

Nimmagadda, Subbaiah Chary ;

Geyer, Christiane ;

Grunert, Katharina ;

Kellmann, Neele ;

Peipp, Matthias ;

Kailayangiri, Sareetha ;

Gutierrez Suburu, Matias Ezequiel ;

Strassert, Cristian A. ;

Schenk, Mathias ;

Greune, Lilo ;

Rueter, Christian ;

Dersch, Petra ;

Hartmann, Wolfgang ;

Rossig, Claudia ;

Neri, Dario ;

Mueller-Tidow, Carsten ;

Schwoeppe, Christian ;

Schliemann, Christoph ;

Khandanpour, Cyrus ;

Lenz, Georg ;

Berdel, Wolfgang E. ;

Baeumer, Sebastian .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022, 15 (01)

[6] Central Nervous System Involvement in Acute Myeloid Leukemia Patients Undergoing Hematopoietic Cell Transplantation [J].

Bar, Merav ;

Tong, Weigang ;

Othus, Megan ;

Loeb, Keith R. ;

Estey, Elihu H. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (03) :546-551

[7]

BENTLEY SA, 1980, BLOOD, V56, P1006

[8] Detection of central nervous system infiltration by Myeloid and lymphoid hematologic neoplasms Using Flow cytometry analysis: Diagnostic accuracy study [J].

Bento, Laiz Camelirao ;

Correia, Rodolfo Patussi ;

Alexandre, Anderson Marega ;

Nosawa, Sonia Tsukasa ;

Pedro, Eduardo de Carvalho ;

Vaz, Andressa da Costa ;

Schimidell, Daniela ;

Peres Fernandes, Gustavo Bruniera ;

Senne Duarte, Carlos Augusto ;

Barroso, Rodrigo de Souza ;

Bacal, Nydia Strachman .

FRONTIERS IN MEDICINE, 2018, 5

[9] Neurological Complications of the Leukemias Across the Ages [J].

Berg, Stephanie ;

Nand, Sucha .

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2017, 17 (02)

[10] The association of leukocyte immunoglobulin-like receptor subfamily B-4 expression in acute myeloid leukemia and central nervous system involvement [J].

Bergstrom, Colin P. ;

Dahiya, Saurabh ;

Chen, Weina ;

Zhang, Cheng Cheng ;

Zhu, Hong ;

Yan, Jingsheng ;

Madanat, Yazan ;

Patel, Prapti ;

Vusirkala, Madhuri ;

Ramakrishnan, Praveen ;

Rizvi, Syed ;

Chung, Stephen ;

Awan, Farrukh ;

Anderson, Larry D. ;

Collins, Robert ;

Kansagra, Ankit .

LEUKEMIA RESEARCH, 2021, 100

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