Could oxygen gradient ektacytometry help to detect sickle cell trait carriers at risk for kidney disorders or exercise-related complications?

被引：0
作者：
Connes, Philippe [1 ]
Nader, Elie [1 ]
机构：
[1] Univ Claude Bernard Lyon 1, Equipe Biol Vasc & Globule Rouge, Lab Interuniv Biol Motr UR7424, Villeurbanne, France
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 04期
关键词：
oxygen gradient ektacytometry; red blood cells; sickle cell; PH;
D O I：
10.1111/bjh.19704
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The study of Ellsworth et al. (Br J Haematol, 2024) demonstrated the usefulness of oxygen gradient ektacytometry technique to better identify the physiological parameters that could increase the risk of sickling of red blood cells (RBCs) from sickle cell trait (SCT) carriers. Oxygen gradient ektacytometry combined with pH and osmolality modulations could help in identifying SCT carriers at risk for kidney disorders or exercise-related complications. Other factors than the percentages of haemoglobin S are probably involved in the propensity of RBCs from SCT carriers to sickle during deoxygenation. Commentary on: Ellsworth et al. Hypertonicity and/or acidosis induce marked rheological changes under hypoxic conditions in sickle trait red blood cells. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19669.
引用
收藏
页码：1260 / 1261
页数：2
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