Non-Coding RNAs and Innate Immune Responses in Cancer

被引：0

作者：

Diaz, Carlos Romero ^{[1
]}

Hernandez-Huerta, Maria Teresa ^{[2
]}

Mayoral, Laura Perez-Campos ^{[3
]}

Villegas, Miriam Emily Avendano ^{[1
]}

Zenteno, Edgar ^{[4
]}

Cruz, Margarito Martinez ^{[1
]}

Mayoral, Eduardo Perez-Campos ^{[3
]}

Canseco, Maria del Socorro Pina ^{[3
]}

Andrade, Gabriel Mayoral ^{[3
]}

Castellanos, Manuel angeles ^{[4
]}

Salvador, Jose Manuel Matias ^{[5
]}

Parada, Eli Cruz ^{[1
]}

Barras, Alexis Martinez ^{[6
]}

Fernandez, Jaydi Nora Cruz ^{[3
]}

Scott-Algara, Daniel ^{[7
]}

Perez-Campos, Eduardo ^{[1
,8
]}

机构：

[1] IT Oaxaca, Tecnol Nacl Mexico, Oaxaca 68030, Mexico

[2] Univ Autonoma Benito Juarez de Oaxaca UABJO, Consejo Nacl Humanidades Ciencias & Tecnol CONAHCy, Fac Med & Cirugia, Oaxaca 68020, Mexico

[3] Univ Autonoma Benito Juarez de Oaxaca UABJO, Fac Med UNAM UABJO, Ctr Invest, Oaxaca 68020, Mexico

[4] Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City 04510, Mexico

[5] Hosp Gen Dr Aurelio Valdivieso, Oaxaca 68040, Mexico

[6] Univ Autonoma Queretaro, Fac Ingn, Queretaro 76017, Mexico

[7] Inst Pasteur, Unite Biol Cellulaire Lymphocytes & Direct Int Aff, F-75015 Paris, France

[8] Lab Patol Clin Dr Eduardo Perez Ortega, Oaxaca 68000, Mexico

来源：

BIOMEDICINES | 2024年 / 12卷 / 09期

关键词：

cancer; piRNA; miRNA; siRNA; specificity; immune-inducible; epimutation; transfer; inheritance; trained immunity; chronic inflammation; EXOSOME-MEDIATED TRANSFER; DNA METHYLATION; THERAPEUTIC TARGETS; SIGNALING PATHWAY; TRAINED IMMUNITY; MESSENGER-RNAS; CIRCULAR RNAS; GENE-TRANSFER; METASTASIS; MACROPHAGE;

D O I：

10.3390/biomedicines12092072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the initiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), with a focus on cancer, innate immunity, and inflammation. We found that ncRNAs are closely related to innate immunity, epigenetics, chronic inflammation, and cancer and share properties such as inducibility, specificity, memory, and transfer. These similarities and interrelationships suggest that ncRNAs and modulators of trained immunity, together with the control of chronic inflammation, can be combined to develop novel therapeutic approaches for personalized cancer treatment. In conclusion, the close relationship between ncRNAs, the innate immune system, and inflammation highlights their importance in cancer pathways and their potential as targets for novel therapeutic strategies.

引用

页数：23

共 216 条

[1] Molecular and Cellular Mechanisms Modulating Trained Immunity by Various Cell Types in Response to Pathogen Encounter [J].

Acevedo, Orlando A. ;

Berrios, Roslye, V ;

Rodriguez-Guilarte, Linmar ;

Lillo-Dapremont, Bastian ;

Kalergis, Alexis M. .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[2] Exercise and weight loss interventions and miRNA expression in women with breast cancer [J].

Adams, Brian D. ;

Arem, Hannah ;

Hubal, Monica J. ;

Cartmel, Brenda ;

Li, Fangyong ;

Harrigan, Maura ;

Sanft, Tara ;

Cheng, Christopher J. ;

Pusztai, Lajos ;

Irwin, Melinda L. .

BREAST CANCER RESEARCH AND TREATMENT, 2018, 170 (01) :55-67

[3] Exploring Potential Epigenetic Biomarkers for Colorectal Cancer Metastasis [J].

Ajithkumar, Priyadarshana ;

Vasantharajan, Sai Shyam ;

Pattison, Sharon ;

McCall, John L. ;

Rodger, Euan J. ;

Chatterjee, Aniruddha .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (02)

[4] Identification of extracellular vesicle microRNA signatures specifically linked to inflammatory and metabolic mechanisms in obesity-associated low type-2 asthma [J].

Alhamdan, Fahd ;

Greulich, Timm ;

Daviaud, Christian ;

Marsh, Leigh M. ;

Pedersen, Frauke ;

Thoelken, Clemens ;

Pfefferle, Petra Ina ;

Bahmer, Thomas ;

Potaczek, Daniel P. ;

Tost, Joerg ;

Garn, Holger .

ALLERGY, 2023, 78 (11) :2944-2958

[5] Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways [J].

Amirfallah, Arsalan ;

Knutsdottir, Hildur ;

Arason, Adalgeir ;

Hilmarsdottir, Bylgja ;

Johannsson, Oskar T. ;

Agnarsson, Bjarni A. ;

Barkardottir, Rosa B. ;

Reynisdottir, Inga .

PLOS ONE, 2021, 16 (11)

[6]

[Anonymous], 2023, Homeostasis Terminology Authored by: Open Learning Initiative

[7]

Aristizbal B., 2013, Autoimmunity: From Bench to Bedside

[8] miR-495-3p regulates sphingolipid metabolic reprogramming to induce Sphk1/ceramide mediated mitophagy and apoptosis in NSCLC [J].

Arora, Shweta ;

Singh, Prithvi ;

Tabassum, Gulnaz ;

Dohare, Ravins ;

Syed, Mansoor Ali .

FREE RADICAL BIOLOGY AND MEDICINE, 2022, 189 :71-84

[9] Advances in Computational Methodologies for Classification and Sub-Cellular Locality Prediction of Non-Coding RNAs [J].

Asim, Muhammad Nabeel ;

Ibrahim, Muhammad Ali ;

Malik, Muhammad Imran ;

Dengel, Andreas ;

Ahmed, Sheraz .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)

[10] MicroRNAs Transfer from Human Macrophages to Hepato-Carcinoma Cells and Inhibit Proliferation [J].

Aucher, Anne ;

Rudnicka, Dominika ;

Davis, Daniel M. .

JOURNAL OF IMMUNOLOGY, 2013, 191 (12) :6250-6260

← 1 2 3 4 5 6 7 8 9 10 →