Effectiveness of Upadacitinib for Patients With Acute Severe Ulcerative Colitis: A Multicenter Experience

被引：26

作者：

Berinstein, Jeffrey A. ^{[1
]}

Karl, Taylor ^{[2
]}

Patel, Anish ^{[3
]}

Dolinger, Michael ^{[4
]}

Barrett, Terrence A. ^{[5
]}

Ahmed, Waseem ^{[2
]}

Click, Ben ^{[2
]}

Steiner, Calen A. ^{[2
]}

Dulaney, David ^{[3
]}

Levine, Jake ^{[1
]}

Hassan, Syed Adeel ^{[5
]}

Perry, Courtney ^{[5
]}

Flomenhoft, Deborah ^{[5
]}

Ungaro, Ryan C. ^{[4
]}

Berinstein, Elliot M. ^{[1
]}

Sheehan, Jessica ^{[1
]}

Cohen-Mekelburg, Shirley ^{[1
,6
]}

Regal, Randolph E. ^{[7
]}

Stidham, Ryan W. ^{[1
]}

Bishu, Shrinivas ^{[1
]}

Colombel, Jean-Frederic ^{[4
]}

Higgins, Peter D. R. ^{[1
]}

机构：

[1] Michigan Med, Dept Internal Med, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA

[2] Univ Colorado, Div Gastroenterol & Hepatol, Anschutz Med Campus, Aurora, CO USA

[3] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Ft Sam Houston, TX USA

[4] Icahn Sch Med Mt Sinai, Div Gastroenterol, New York, NY USA

[5] Univ Kentucky, Div Digest Dis & Nutr, Lexington, KY USA

[6] VA Ann Arbor Hlth Care Syst, VA Ctr Clin Management Res, Ann Arbor, MI USA

[7] Michigan Med, Dept Pharm Serv, Ann Arbor, MI USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2024年 / 119卷 / 07期

关键词：

acute severe ulcerative colitis; ulcerative colitis; Janus kinase inhibitors; upadacitinib; CYCLOSPORINE; INFLIXIMAB; THERAPY;

D O I：

10.14309/ajg.0000000000002674

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION:A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.METHODS:Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions.RESULTS:Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted.DISCUSSION:Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC.

引用

页码：1421 / 1425

页数：5

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