Nickel-Catalyzed Regio- and Stereoselective Reductive Alkylative Cyclization of 1,6-Enynes with Alkyl Bromides

被引：0

作者：

Xing, Yunxin ^{[1
]}

Tian, Zhu ^{[1
]}

Shen, Kun ^{[1
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Radiol, Wuhan 430071, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Reductive cross-coupling; Nickel; Cyclization; 1,6-enyne; ARYLATIVE CYCLIZATION; ALLYL ELECTROPHILES; COUPLING REACTIONS; CASCADE REACTIONS; HALIDES; VINYL;

D O I：

10.1002/adsc.202400575

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A nickel-catalyzed reductive alkylative cyclization of 1,6-enynes with alkyl bromides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and introduces alkyl groups regio- and stereoselectively into the products. This method provides a platform for the synthesis of carbo- and heterocycles that are widely found in many natural products and biologically active molecules. image

引用

页码：3802 / 3807

页数：6

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