Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients

被引：0

作者：

Zhang, Hao ^{[1
]}

Tsuchikawa, Takahiro ^{[2
]}

Takeuchi, Satoshi ^{[3
,4
]}

Hirata, Kenji ^{[5
]}

Tanaka, Kimitaka ^{[2
]}

Matsui, Aya ^{[2
]}

Nakanishi, Yoshitsugu ^{[2
]}

Asano, Toshimichi ^{[2
]}

Noji, Takehiro ^{[2
]}

Nakamura, Toru ^{[2
]}

Takeuchi, Shintaro ^{[2
]}

Wada, Masataka ^{[2
]}

Hirano, Satoshi ^{[2
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Hepatobiliary & Pancreat Surg, Chengdu 610072, Peoples R China

[2] Hokkaido Univ, Dept Gastroenterol Surg 2, Fac Med, Kita 15 Nishi 7,Kita Ku, Sapporo 0608638, Japan

[3] Hokkaido Univ, Fac Med, Dept Med Oncol, Sapporo 0608638, Japan

[4] Hokkaido Univ, Grad Sch Med, Sapporo 0608638, Japan

[5] Hokkaido Univ, Grad Sch Med, Dept Diagnost Imaging, Sapporo 0608638, Japan

来源：

ENDOCRINE JOURNAL | 2024年 / 71卷 / 09期

关键词：

Gastroenteropancreatic neuroendocrine tumor; NETest; Japanese population; Application value; Peptide receptor radionuclide therapy; TRANSCRIPT ANALYSIS; DIAGNOSIS; PREDICTS; DEFINES; UTILITY; DISEASE; PRRT;

D O I：

10.1507/endocrj.EJ24-0090

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As novel biomarkers for gastroenteropancreatic neuroendocrine tumors (GEPNET) are in demand, we aimed to validate the clinical value of the NETest in Japanese patients. Between 2021 and 2023, blood and clinical data were collected from patients with GEPNET. Among 35 patients (median age: 59 [49-66] years), 27 cases originated from the pancreas and eight from the gastrointestinal tract. Of 69 samples sent to the laboratory, 56 (81.2%) underwent NETest. The diagnostic sensitivity was 97.1%. Among three patients who underwent R0 resection and four treated with peptide receptor radionuclide therapy, the changes in NETest scores closely correlated with disease progression. The NETest demonstrated high diagnostic efficacy and accurate therapeutic monitoring capabilities in a Japanese population.

引用

页码：873 / 880

页数：8

共 20 条

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