Mesoporous silica and alumina nanoparticles to improve drug delivery of pioglitazone on diabetic type 1 nephropathy in rats

被引:0
作者
Varshosaz, Jaleh [1 ,2 ]
Ahmadipour, Saeedeh [3 ,4 ]
Dezhangfard, Armin [5 ]
机构
[1] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut, Esfahan, Iran
[2] Isfahan Univ Med Sci, Novel Drug Delivery Syst Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan, Iran
[3] Lorestan Univ Med Sci, Sch Pharm, Dept Pharmaceut, Khorramabad, Iran
[4] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran
[5] Lorestan Univ Med Sci, Student Res Comm, Khorramabad, Iran
关键词
Diabetic nephropathy; Mesoporous alumina; Mesoporous silica; Pioglitazone; Poorly water-soluble; ORAL BIOAVAILABILITY; IN-VITRO; RELEASE;
D O I
10.4103/RPS.RPS_65_23
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Background and purpose: Diabetic nephropathy leads to end-stage renal disease. The present study aimed to evaluate the prophylactic effect of pioglitazone-loaded mesoporous silica and alumina scaffold on renal function and the underlying mechanisms in streptozotocin-induced diabetic rats.Experimental approach: The mesoporous nanoparticles were synthesized by chemical methods from tetraethylorthosilicate and aluminum isopropoxide and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The soaking method was applied to load pioglitazone into the mesoporous silica and alumina. Subsequently, the most capable formulation was evaluated for lipid profile, blood glucose, renal function biomarkers, malondialdehyde, and kidney histopathological changes in diabetic rats.Findings/Results: Pioglitazone loaded in the mesoporous included a superior release of about 80%. No interaction was observed in Fourier transform infrared spectroscopy and X-ray diffraction was shown crystalline. Scanning electron microscopy showed the size of the nanometer in the range of 100 - 300 nm. Mesoporous silica containing the drug significantly decreased urinary parameters, triglycerides, low-density lipoprotein, blood urea nitrogen, blood glucose, malondialdehyde, and creatinine. In addition, it showed increased high-density lipoprotein, significantly. The renal histopathological changes indicated improvement compared with the untreated diabetic group.Conclusion and implications: It was concluded that the mesoporous was potent to serve as a promising drug carrier and a platform aimed at the delivery of poorly water-soluble drugs for improving oral bioavailability. Furthermore, it has the potential to provide a beneficial effect on the changes in diabetic parameters.
引用
收藏
页码:459 / 474
页数:16
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