Testing effectiveness and implementation of a standardized approach to sexual dysfunction screening among adolescent and young adult-aged survivors of childhood cancer: A type I hybrid, mixed methods trial protocol

被引:0
作者
Demedis, Jenna [1 ,2 ]
Reedy, Julia [3 ]
Miller, Kristen [1 ]
Hu, Junxiao [1 ]
Klosky, James L. [4 ,5 ]
Holliman, Brooke Dorsey [3 ,6 ]
Peterson, Pamela N. [7 ,8 ]
Chow, Eric J. [9 ]
Studts, Christina [1 ,3 ]
机构
[1] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA
[2] Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Aurora, CO 80045 USA
[3] Univ Colorado, Adult & Child Ctr Hlth Outcomes Res & Delivery Sci, Sch Med, Aurora, CO USA
[4] Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders Ctr, Atlanta, GA USA
[5] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA
[6] Univ Colorado, Sch Med, Dept Family Med, Aurora, CO USA
[7] Univ Colorado, Sch Med, Dept Internal Med, Aurora, CO USA
[8] Denver Hlth Med Ctr, Denver, CO USA
[9] Fred Hutchinson Canc Ctr, Clin Res & Publ Hlth Sci Div, Washington, DC USA
来源
PLOS ONE | 2024年 / 19卷 / 07期
关键词
HEALTH; INTERVIEWS; ONCOLOGY;
D O I
10.1371/journal.pone.0305677
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Approximately 20-50% of adolescent and young adult-aged childhood cancer survivors (AYA-CCS) experience sexual dysfunction (SD), although this healthcare need is widely underrecognized. Previous research from both AYA-CCS patients and their providers report that SD needs are unaddressed despite patient desires for SD discussions to be incorporated as part of their care. Patients and providers agree that standardized use of a patient-reported outcome measure may facilitate SD discussions; an SD screening approach was developed with patient and provider input. This study will measure the effectiveness of a standardized SD screening intervention and assess implementation outcomes and multilevel barriers and facilitators to guide future research.Methods This multi-site, mixed methods, type 1 effectiveness-implementation hybrid trial will be evaluated using a pre-post design (NCT05524610). The trial will enroll 86 AYA-CCS (ages 15-39) from two cancer centers in the United States. The SD intervention consists of core fundamental functions with a "menu" of intervention options to allow for flexibility in delivery and tailoring in variable contexts. Effectiveness of the intervention on facilitating SD communication will be measured through patient surveys and clinical data; multivariable logistic regression will be used for the binary outcome of self-reported SD screening, controlling for patient-level predictors. Implementation outcomes will be assessed using mixed methods (electronic health record abstraction, patient and provider surveys, and provider interviews. Quantitative and qualitative findings will be merged using a joint display to understand factors affecting intervention success.Implications Identification and treatment of SD in AYA-CCS is an important and challenging quality of life concern. The type 1 hybrid design will facilitate rapid translation from research to practice by testing the effects of the intervention while simultaneously identifying multilevel barriers and facilitators to real-world implementation. This approach will inform future testing and dissemination of the SD screening intervention.
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页数:18
相关论文
共 52 条
[1]   Sexual Functioning Among Young Adult Cancer Patients: A 2-Year Longitudinal Study [J].
Acquati, Chiara ;
Zebrack, Brad J. ;
Faul, Anna C. ;
Embry, Leanne ;
Aguilar, Christine ;
Block, Rebecca ;
Hayes-Lattin, Brandon ;
Freyer, David R. ;
Cole, Steve .
CANCER, 2018, 124 (02) :398-405
[2]   Mixed-methods approach to evaluate an mHealth intervention to increase adherence to triage of human papillomavirus-positive women who have performed self-collection (the ATICA study): study protocol for a hybrid type I cluster randomized effectiveness-implementation trial [J].
Arrossi, Silvina ;
Paolino, Melisa ;
Orellana, Liliana ;
Thouyaret, Laura ;
Kohler, Racquel E. ;
Viswanath, Kasisomayajula .
TRIALS, 2019, 20 (1)
[3]  
Bjornard KL., 2020, Jude Lifetime Cohort Study. J Sex Med
[4]   Improvement in sexual function after ovarian cancer: Effects of sexual therapy and rehabilitation after treatment for ovarian cancer [J].
Bober, Sharon L. ;
Recklitis, Christopher J. ;
Michaud, Alexis L. ;
Wright, Alexi A. .
CANCER, 2018, 124 (01) :176-182
[5]   Sexual Function in Childhood Cancer Survivors: A Report from Project REACH [J].
Bober, Sharon L. ;
Zhou, Eric S. ;
Chen, Bing ;
Manley, Peter E. ;
Kenney, Lisa B. ;
Recklitis, Christopher J. .
JOURNAL OF SEXUAL MEDICINE, 2013, 10 (08) :2084-2093
[6]   A pilot intervention to enhance psychosexual development in adolescents and young adults with cancer [J].
Canada, Andrea L. ;
Schover, Leslie R. ;
Li, Yisheng .
PEDIATRIC BLOOD & CANCER, 2007, 49 (06) :824-828
[7]   Romantic and Sexual Relationships, Body Image, and Fertility in Adolescent and Young Adult Testicular Cancer Survivors: A Review of the Literature [J].
Carpentier, Melissa Y. ;
Fortenberry, J. Dennis .
JOURNAL OF ADOLESCENT HEALTH, 2010, 47 (02) :115-125
[8]   Interventions to Address Sexual Problems in People With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Adaptation of Cancer Care Ontario Guideline [J].
Carter, Jeanne ;
Lacchetti, Christina ;
Andersen, Barbara L. ;
Barton, Debra L. ;
Bolte, Sage ;
Damast, Shari ;
Diefenbach, Michael A. ;
DuHamel, Katherine ;
Florendo, Judith ;
Ganz, Patricia A. ;
Goldfarb, Shari ;
Hallmeyer, Sigrun ;
Kushner, David M. ;
Rowland, Julia H. .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (05) :492-+
[9]  
Children's Oncology Group, 2018, Long-term follow up guidelines for survivors of childhood, adolescent and young adult cancer
[10]   Adolescent and Young Adult Oncology, Version 2.2018 [J].
Coccia, Peter F. ;
Pappo, Alberto S. ;
Beaupin, Lynda ;
Borges, Virginia F. ;
Borinstein, Scott C. ;
Chugh, Rashmi ;
Dinner, Shira ;
Folbrecht, Jeanelle ;
Frazier, A. Lindsay ;
Goldsby, Robert ;
Gubin, Alexandra ;
Hayashi, Robert ;
Huang, Mary S. ;
Link, Michael P. ;
Livingston, John A. ;
Matloub, Yousif ;
Millard, Frederick ;
Oeffinger, Kevin C. ;
Puccetti, Diane ;
Reed, Damon ;
Robinson, Steven ;
Rosenberg, Abby R. ;
Sanft, Tara ;
Spraker-Perlman, Holly L. ;
von Mehren, Margaret ;
Wechsler, Daniel S. ;
Whelan, Kimberly F. ;
Yeager, Nicholas ;
Gurski, Lisa A. ;
Shead, Dorothy A. .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2018, 16 (01) :66-97