Role of combined surgical and radiotherapy treatment in nonmetastatic WHO I nasopharyngeal carcinoma patients

被引:0
作者
Wang, Zi-meng [1 ,2 ,3 ,4 ]
Zhu, Si-yu [5 ]
Wang, Qin [1 ,2 ,3 ,4 ]
Duan, Chong-yang [5 ]
Liu, Si-han [1 ,2 ,3 ,4 ]
You, Rui [1 ,2 ,3 ,4 ,6 ]
Chen, Ming-Yuan [1 ,2 ,3 ,4 ,6 ]
Huang, Pei-Yu [1 ,2 ,3 ,4 ]
机构
[1] State Key Lab Oncol South China, Guangzhou, Peoples R China
[2] Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Guangzhou, Peoples R China
[3] Guangdong Prov Clin Res Ctr Canc, Guangzhou, Peoples R China
[4] Sun Yat Sen Univ, Canc Ctr, Guangzhou, Peoples R China
[5] Southern Med Univ, Sch Publ Hlth, Dept Biostat, Guangzhou, Peoples R China
[6] Sun Yat Sen Univ, Affiliated Hosp 5, Nasopharyngeal Canc Ctr, Zhuhai 519000, Peoples R China
关键词
Head and neck cancer; WHO I nasopharyngeal cancer; radiotherapy; surgery; SQUAMOUS-CELL CARCINOMA; POSTOPERATIVE RADIOTHERAPY; SURVIVAL; HEAD; EPIDEMIOLOGY; RISK;
D O I
10.1080/00016489.2024.2378467
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
BackgroundKeratinizing squamous cell carcinoma (KSCC) is recognized as WHO I nasopharyngeal carcinoma (NPC). Current guidelines for treating nasopharyngeal cancer do not delineate specific strategies for individual pathologic subtypes. ObjectivesTo explore the optimal treatment for KSCC of the nasopharynx. Material and methodsData on patients were extracted from the SEER database. Survival differences between patients treated with radiotherapy alone and combined surgery were assessed using Kaplan-Meier and Cox regression models and compared using propensity score matching (PSM). In addition, we explored the survival differences between the two groups of patients in different risk stratifications. ResultsIn our study, 165 patients underwent surgical intervention, while 1238 patients did not. In both univariate (CSS: p = .001, HR = 0.612; OS: p < .001, HR = 0.623) and multivariate (CSS: p = .004, HR = 0.655; OS: p < .001, HR = 0.655) analyses, combined surgery was identified as a significant prognostic factor. These findings were consistent after PSM. Using RPA, patients were categorized into two groups. CSS improved in the high-risk group, whereas the difference in low-risk patients was not significant. Conclusions and significanceFor patients diagnosed with WHO I nasopharyngeal carcinoma, the combination of radiotherapy and surgery has significant clinical advantages, especially for patients at high risk.
引用
收藏
页码:325 / 332
页数:8
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