Mechanisms of Transsynaptic Degeneration in the Aging Brain

被引：1

作者：

Wall, Roshana Vander ^{[1
]}

Basavarajappa, Devaraj ^{[1
]}

Klistoner, Alexander ^{[1
]}

Graham, Stuart ^{[1
,2
]}

You, Yuyi ^{[1
,2
]}

机构：

[1] Macquarie Univ, Fac Med Hlth & Human Sci, N Ryde, NSW 2109, Australia

[2] Univ Sydney, Save Sight Inst, Sydney, NSW 2000, Australia

来源：

AGING AND DISEASE | 2024年 / 15卷 / 05期

关键词：

Transsynaptic Degeneration; Glia; Senescence; Neurodegenerative Disease; Aging; LATERAL GENICULATE-NUCLEUS; NEURONAL CELL-DEATH; AXONAL DEGENERATION; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; VISUAL PATHWAY; INDUCED DEMYELINATION; TIME-COURSE; MICROGLIA; RECEPTOR;

D O I：

10.14336/AD.2024.03019

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A prominent feature in many neurodegenerative diseases involves the spread of the pathology from the initial site of damage to anatomically and functionally connected regions of the central nervous system (CNS), referred to as transsynaptic degeneration (TSD). This review covers the possible mechanisms of both retrograde and anterograde TSD in various age-related neurodegenerative diseases, including synaptically and glial mediated changes contributing to TDS and their potential as therapeutic targets. This phenomenon is well documented in clinical and experimental studies spanning various neurodegenerative diseases and their respective models, with a significant emphasis on the visual pathway, to be explored herein. With the increase in the aging population and subsequent rise in age-related neurodegenerative diseases, it is crucial to understand the underlying mechanisms of

引用

页码：2149 / 2167

页数：19

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