The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities

被引：6

作者：

Zhang, Kexin ^{[1
,2
]}

Zhang, Qi ^{[1
]}

Qiu, Hongyan ^{[1
,2
]}

Ma, Yanhui ^{[3
]}

Hou, Ningning ^{[1
,2
]}

Zhang, Jingwen ^{[1
,2
]}

Kan, Chengxia ^{[1
,2
]}

Han, Fang ^{[1
,2
,3
]}

Sun, Xiaodong ^{[1
,2
]}

Shi, Junfeng ^{[1
,2
]}

机构：

[1] Shandong Second Med Univ, Affiliated Hosp, Sch Clin Med, Dept Endocrinol & Metab, Weifang, Peoples R China

[2] Shandong Second Med Univ, Affiliated Hosp, Clin Res Ctr, Weifang, Peoples R China

[3] Shandong Second Med Univ, Affiliated Hosp, Dept Pathol, Weifang, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Gut microbiome; Obesity; Microbiota; Metabolic disorders; Mechanisms; Clinical applications; CHAIN FATTY-ACIDS; ADIPOSE-TISSUE; FAECALIBACTERIUM-PRAUSNITZII; INTESTINAL MICROENVIRONMENT; PROBIOTICS; DIET; OVERWEIGHT; HEALTH; BROWN; INFLAMMATION;

D O I：

10.1016/j.heliyon.2024.e37609

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microbial interactions are widespread and important processes that support the link between disease and microbial ecology. The gut microbiota is a major source of microbial stimuli that can have detrimental or beneficial effects on human health. It is also an endocrine organ that maintains energy homeostasis and host immunity. Obesity is a highly and increasingly prevalent metabolic disease and the leading cause of preventable death worldwide. An imbalance in the gut microbiome is associated with several diseases including obesity-related metabolic disorders. This review summarizes the complex association between the gut microbiome and obesity-associated metabolic diseases and validates the role and mechanisms of ecological dysregulation in the gut in obesity-associated metabolic disorders. Therapies that could potentially alleviate obesityassociated metabolic diseases by modulating the gut microbiota are discussed.

引用

页数：11

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