The Molecular and Immunological Landscape of Meningiomas

被引：5

作者：

Lotsch, Catharina ^{[1
]}

Warta, Rolf ^{[1
]}

Herold-Mende, Christel ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Dept Neurosurg, Div Expt Neurosurg, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期

关键词：

meningioma; molecular profiling; DNA methylation; immunobiology; infiltrating immune cells; immunotherapy; meningioma prognosis; brain tumor diagnostics; CLASSIFICATION; CANCER; MULTICENTER; INHIBITION; EXPRESSION; HALLMARKS; SYSTEM; PD-L1;

D O I：

10.3390/ijms25179631

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Meningiomas are the most common primary intracranial tumors in adults and typically have a slow-growing and benign nature. However, there is also a substantial subset of meningiomas that shows aggressive clinical behavior and is refractory to standard treatment modalities, which are still limited to surgery and/or radiotherapy. Despite intensive research, no systemic treatment options are yet available in the clinic for these challenging tumors, resulting in poor patient outcome. Intensive research on the molecular pathogenesis of meningiomas has led to improved diagnostic tools, but so far there is no standardized implementation for the molecular profiling of these tumors for clinical practice. Recent research advances have also focused on the immunophenotyping of meningiomas, leading to several clinical trials examining the use of immune checkpoint blockade therapy in patients with clinically aggressive subtypes. In this review, we aim to summarize the current knowledge on the molecular and immunological landscape of meningiomas in detail and provide current and progressive ideas for future directions.

引用

页数：13

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