Single-Ce11 Analysis Reveals Is1et Autoantigen's Immune Activation in Type 1 Diabetes Patients

被引：0

作者：

Okamura, Takuro ^{[1
]}

Kitagawa, Noriyuki ^{[2
]}

Kitagawa, Nobuko ^{[1
]}

Sakai, Kimiko ^{[1
]}

Sumi, Madoka ^{[1
]}

Kobayashi, Genki ^{[1
]}

Imai, Dan ^{[1
]}

Matsui, Takaaki ^{[1
]}

Hamaguchi, Masahide ^{[1
]}

Fukui, Michiaki ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, 465 Kajii cho,Kamigyo ku, Kyoto, Kyoto 6028566, Japan

[2] Kameoka Municipal Hosp, Dept Diabetol, Kameoka 6218585, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2024年

关键词：

CD8+T cells; CD4+T cells; granulocytes; natural killer cells; dendritic cells; monocytes; T-CELLS; MONOCLONAL-ANTIBODY; ANTIGEN; OVEREXPRESSION; EXPRESSION; RESPONSES; PREVENTS; SUBSET; BLOOD;

D O I：

10.3164/jcbn.24-86

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

patients with overlapping peptides of glutamic acid decarboxylase (GAD), islet antigen 2 (IA-2), and insulin antigens, and performed gene expression analysis by single-cell variable-diversity-joining (VDJ) sequencing and T cell receptor repertoire analysis. Twenty male patients with type 1 diabetes mellitus (T1DM) participating in the KAMOGAWA-DM cohort were included. Four of them were randomly selected for

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