Circulating miRNA-21 as early potential diagnostic biomarker for acute myocardial infarction: a meta-analysis

被引：0
作者：
Wang, Ke [1 ,2 ]
Li, Kai [3 ]
Li, Zhuoyuan [1 ,2 ]
Yan, Xizhang [1 ]
机构：
[1] Xian Med Univ, Dept Clin Med, Xian, Shannxi, Peoples R China
[2] Xian Med Univ, Dept Project Prevent & Treatment Resp Dis, Xian, Shannxi, Peoples R China
[3] Xian Med Univ, Hanjiang Hosp, Dept Emergency, Hanzhong, Shannxi, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2024年 / 11卷
关键词：
AMI; promising biomarker; miRNA-21; meta-analysis; miR-21; DISEASE; MICRORNA-21; EXPRESSION; PLASMA; SERUM;
D O I：
10.3389/fcvm.2024.1330884
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: There exists a knowledge gap concerning the clinical significance of miRNA-21; therefore, in the present study, we aimed to estimate the diagnostic and prognostic accuracy and sensitivity of miRNA-21 in acute myocardial infarction (AMI) by performing an evidence-based meta-analysis of previous AMI-related clinical studies. Methods: Chinese and English literature published before April 2024 were searched, and data were reviewed and extracted. After quality appraisal, the STATA 16.0 software was used for the effect size analysis of the various treatments described in the literature. Results: A total of 14 valid documents were retrieved from 562 studies. The results of the systematic review revealed that for the patients with AMI vs. those without non-AMI, the aggregated odds ratio reached 5.37 (95% confidence interval 3.70-7.04). The general sensitivity and specificity for the circulating miRNA-21 levels in diagnosing AMI were 0.83 and 0.81, respectively. Discussion: Thus, the meta-analysis of 14 AMI-related clinical trials highlighted that miRNA-21 may serve as a promising biomarker for diagnosing AMI.
引用
收藏
页数：13
相关论文
共 35 条
  • [1] Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging
    Ali Sheikh, Md Sayed
    [J]. CARDIOLOGY RESEARCH AND PRACTICE, 2020, 2020
  • [2] Biogenesis and Regulation of Cardiovascular MicroRNAs
    Bauersachs, Johann
    Thum, Thomas
    [J]. CIRCULATION RESEARCH, 2011, 109 (03) : 334 - 347
  • [3] Prevention of heart failure with preserved ejection fraction (HFpEF): reexamining microRNA-21 inhibition in the era of oligonucleotide-based therapeutics
    Ben-Nun, David
    Buja, L. Maximilian
    Fuentes, Francisco
    [J]. CARDIOVASCULAR PATHOLOGY, 2020, 49
  • [4] Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000659, 10.1161/CIR.0000000000000746]
  • [5] Dynamic Changes in miR-21 Regulate Right Ventricular Dysfunction in Congenital Heart Disease-Related Pulmonary Arterial Hypertension
    Chang, Wei-Ting
    Wu, Chia-Chun
    Lin, Yu-Wen
    Shih, Jhih-Yuan
    Chen, Zhih-Cherng
    Wu, Sheng-Nan
    Wu, Chia-Ching
    Hsu, Chih-Hsin
    [J]. CELLS, 2022, 11 (03)
  • [6] The Cell Type-Specific Functions of miR-21 in Cardiovascular Diseases
    Dai, Beibei
    Wang, Feng
    Nie, Xiang
    Du, Hengzhi
    Zhao, Yanru
    Yin, Zhongwei
    Li, Huaping
    Fan, Jiahui
    Wen, Zheng
    Wang, Dao Wen
    Chen, Chen
    [J]. FRONTIERS IN GENETICS, 2020, 11
  • [7] Clinical significance and correlation of microRNA-21 expression and the neutrophil-lymphocyte ratio in patients with acute myocardial infarction
    Gao, Changkui
    Zhao, Dan
    Wang, Jingjing
    Liu, Ping
    Xu, Baohe
    [J]. CLINICS, 2019, 74
  • [8] Diagnostic and prognostic value of miR-1 and miR-29b on adverse ventricular remodeling after acute myocardial infarction - The SITAGRAMI-miR analysis
    Grabmaier, U.
    Clauss, S.
    Gross, L.
    Klier, I.
    Franz, W. M.
    Steinbeck, G.
    Wakili, R.
    Theiss, H. D.
    Brenner, C.
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 244 : 30 - 36
  • [9] Mechanisms of disease - Inflammation, atherosclerosis, and coronary artery disease
    Hansson, GK
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (16) : 1685 - 1695
  • [10] COMPARATIVE ANALYSIS OF MIRNA EXPRESSION IN SERUM AND PLASMA OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
    Hermenegildo, C.
    Mompeon, A.
    Januario, T.
    Vidal-Gomez, X.
    Pujol, M.
    Perez-Cremades, D.
    Garcia-Blas, S.
    Ortega, L.
    Sanchis, J.
    Dantas, A. P.
    Novella, S.
    [J]. JOURNAL OF HYPERTENSION, 2017, 35 : E204 - E204
1234