Factors Associated with False Positive Breast Cancer Results in the Real-Time Sonoelastography Evaluation of Solid Breast Lesions

被引:0
|
作者
Eremici, Ivana [1 ]
Borlea, Andreea [2 ]
Dumitru, Catalin [3 ]
Stoian, Dana [2 ]
机构
[1] Victor Babes Univ Med & Pharm, PhD Sch, Timisoara 300041, Romania
[2] Victor Babes Univ Med & Pharm, Dept Internal Med 2, Timisoara 300041, Romania
[3] Victor Babes Univ Med & Pharm, Obstet & Gynecol Dept, Timisoara 300041, Romania
来源
MEDICINA-LITHUANIA | 2024年 / 60卷 / 07期
关键词
breast cancer screening; real-time sonoelastography; false positive; women; BI-RADS; CLINICAL-APPLICATION; ULTRASOUND; ELASTOGRAPHY; US; MAMMOGRAPHY; ACCURACY; WOMEN; DIAGNOSIS; SYSTEM;
D O I
10.3390/medicina60071023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Breast cancer is one of the most widespread cancers among the female population around the world and is curable if diagnosed in an early stage. Consequently, breast cancer screening imaging techniques have greatly evolved and adjusted over the last decades. Alongside mammography, sonoelastography became an important tool for breast cancer detection. However, sonoelastography still has its limitations, namely, there is still a high occurrence of false positive results in the BIRADS 4 category. The aim of our study is to identify potential false positive predictors and to ascertain the factors influencing the quality of strain ultrasound elastography for the evaluation of suspicious solid breast lesions categorized as BIRADS 4B, 4C, and 5. Materials and Methods: We conducted a retrospective study in a single private medical center in Timisoara between January 2017 and January 2022 analyzing 1625 solid breast lesions by the sonoelastography strain using a standardized BIRADS-US lexicon. Results: Our study showed that most sonoelastography factors linked to incorrect and overdiagnosis were due to a nodule dimension (OR = 1.02 per unit increase), posterior acoustic shadowing (OR = 12.26), reactive adenopathy (OR = 6.35), and an increased TES score (TES3 OR = 6.60; TES4 OR = 23.02; TES5 OR = 108.24). Regarding patient characteristics, age (OR = 1.09 per unit increase), BMI, (OR = 1.09 per unit increase), and breastfeeding history (OR = 3.00) were observed to increase the likelihood of false positive results. On the other hand, the nodules less likely to be part of the false positive group exhibited the following characteristics: a regular shape (OR = 0.27), homogenous consistency (OR = 0.42), and avascularity (OR = 0.22). Conclusions: Older age, high BMI, patients with a breastfeeding history, and those who exhibit the following specific nodule characteristics were most often linked to false positive results: large tumors with posterior acoustic shadowing and high elasticity scores, accompanied by reactive adenopathy. On the other hand, homogenous, avascular nodules with regular shapes were less likely to be misdiagnosed.
引用
收藏
页数:18
相关论文
共 50 条
  • [11] Risk of breast cancer after false-positive results in mammographic screening
    Roman, Marta
    Castells, Xavier
    Hofvind, Solveig
    von Euler-Chelpin, My
    CANCER MEDICINE, 2016, 5 (06): : 1298 - 1306
  • [12] Variations in the Elasticity of Breast Tissue During the Menstrual Cycle Determined by Real-time Sonoelastography
    Wojcinski, Sebastian
    Cassel, Michael
    Farrokh, Andre
    Soliman, Amr A.
    Hille, Ursula
    Schmidt, Werner
    Degenhardt, Friedrich
    Hillemanns, Peter
    JOURNAL OF ULTRASOUND IN MEDICINE, 2012, 31 (01) : 63 - 72
  • [13] False-negative results of breast MR computer-aided evaluation in patients with breast cancer: correlation with clinicopathologic and radiologic factors
    Shin, YunKyung
    Sohn, Yu-Mee
    Seo, Mirinae
    Han, Kyunghwa
    CLINICAL IMAGING, 2016, 40 (06) : 1086 - 1091
  • [14] Improving B mode ultrasound evaluation of breast lesions with real-time ultrasound elastography - A clinical approach
    Tan, S. M.
    Teh, H. S.
    Mancer, J. F. Kent
    Poh, W. T.
    BREAST, 2008, 17 (03) : 252 - 257
  • [15] Breast cancer risk, worry, and anxiety: Effect on patient perceptions of false-positive screening results
    Lee, Janie M.
    Lowry, Kathryn P.
    Chubiz, Jessica E. Cott
    Swan, J. Shannon
    Motazedi, Tina
    Halpern, Elkan F.
    Tosteson, Anna N. A.
    Gazelle, G. Scott
    Donelan, Karen
    BREAST, 2020, 50 : 104 - 112
  • [16] Real-time sonoelastography performed in addition to B-mode ultrasound and mammography:: Improved differentiation of breast lesions?
    Thomas, Anke
    Kuemmel, Sherko
    Fritzsche, Florian
    Warm, Mathias
    Ebert, Bernd
    Hamm, Bernd
    Fischer, Thomas
    ACADEMIC RADIOLOGY, 2006, 13 (12) : 1496 - 1504
  • [17] Evaluation of real-time qualitative sonoelastography of focal lesions in the parotid and submandibular glands: applications and limitations
    Kunwar S. S. Bhatia
    Darshana D. Rasalkar
    Yim-Ping Lee
    Ka-Tak Wong
    Ann D. King
    Hok-Yuen Yuen
    Anil T. Ahuja
    European Radiology, 2010, 20 : 1958 - 1964
  • [18] Evaluation of real-time qualitative sonoelastography of focal lesions in the parotid and submandibular glands: applications and limitations
    Bhatia, Kunwar S. S.
    Rasalkar, Darshana D.
    Lee, Yim-Ping
    Wong, Ka-Tak
    King, Ann D.
    Yuen, Hok-Yuen
    Ahuja, Anil T.
    EUROPEAN RADIOLOGY, 2010, 20 (08) : 1958 - 1964
  • [19] The Cumulative Risk of False-Positive Results in the Norwegian Breast Cancer Screening Program: Updated Results
    Roman, Marta
    Hubbard, Rebecca A.
    Sebuodegard, Sofie
    Miglioretti, Diana L.
    Castells, Xavier
    Hofvind, Solveig
    CANCER, 2013, 119 (22) : 3952 - 3958
  • [20] Multicenter Study of Ultrasound Real-Time Tissue Elastography in 779 Cases for the Assessment of Breast Lesions: Improved Diagnostic Performance by Combining the BI-RADS®-US Classification System with Sonoelastography
    Wojcinski, S.
    Farrokh, A.
    Weber, S.
    Thomas, A.
    Fischer, T.
    Slowinski, T.
    Schmidt, W.
    Degenhardt, F.
    ULTRASCHALL IN DER MEDIZIN, 2010, 31 (05): : 484 - 491