Unlocking the possibilities of therapeutic potential of silymarin and silibinin against neurodegenerative Diseases-A mechanistic overview

被引：2

作者：

Ashique, Sumel ^{[1
,2
]}

Mohanto, Sourav ^{[3
]}

Kumar, Nitish ^{[4
]}

Nag, Sagnik ^{[5
]}

Mishra, Anuradha ^{[6
]}

Biswas, Aritra ^{[7
,8
]}

Rihan, Mohd ^{[9
]}

Srivastava, Shriyansh ^{[10
,11
]}

Bhowmick, Mithun ^{[2
]}

Taghizadeh-Hesary, Farzad ^{[12
]}

机构：

[1] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[2] Bengal Coll Pharmaceut Sci & Res, Dept Pharmaceut, Durgapur 713212, W Bengal, India

[3] Yenepoya Univ, Yenepoya Pharm Coll & Res Ctr, Dept Pharmaceut, Mangalore 575018, Karnataka, India

[4] SRM Inst Sci & Technol, SRM Modinagar Coll Pharm, Delhi NCR Campus, Ghaziabad 201204, Uttar Pradesh, India

[5] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia

[6] Amity Univ, Amity Inst Pharm, Lucknow Campus, Noida 226010, Uttar Pradesh, India

[7] Ramakrishna Mission Vivekananda Centenary Coll, Dept Microbiol, Rahara Akhil Mukherjee Rd, Khardaha 700118, W Bengal, India

[8] Govt India, UNESCO Reg Ctr Biotechnol, Dept Biotechnol, NCR Biotech Sci Cluster, Faridabad 121001, Haryana, India

[9] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmacol, SAS Nagar 160062, Punjab, India

[10] Galgotias Univ, Sch Med & Allied Sci, Dept Pharm, Greater Noida 203201, India

[11] Delhi Pharmaceut Sci & Res Univ DPSRU, Dept Pharmacol, 3 Sect Pushp Vihar, New Delhi 110017, India

[12] Iran Univ Med Sci, Senses Hlth Inst F, ENT & Headand Neck Res Ctr & Dept, Sch Med, Tehran, Iran

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2024年 / 981卷

关键词：

Silymarin; Silibinin; Neurodegenerative diseases; Parkinson; Alzheimer; Anti-oxidant; NF-KAPPA-B; MANGANESE-INDUCED NEUROTOXICITY; INDUCED PARKINSONS-DISEASE; THISTLE SILYBUM-MARIANUM; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; CEREBRAL-ISCHEMIA; MOUSE MODEL; INFLAMMATORY CYTOKINES; NATURAL ANTIOXIDANT;

D O I：

10.1016/j.ejphar.2024.176906

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Silymarin, a bioflavonoid derived from the Silybum marianum plant, was discovered in 1960. It contains C 25 and has been extensively used as a therapeutic agent against liver-related diseases caused by alcohol addiction, acute viral hepatitis, and toxins-inducing liver failure. Its efficacy stems from its role as a potent anti-oxidant and scavenger of free radicals, employed through various mechanisms. Additionally, silymarin or silybin possesses immunomodulatory characteristics, impacting immune-enhancing and immune-suppressive functions. Recently, silymarin has been recognized as a potential neuroprotective therapy for various neurological conditions, including Parkinson's and Alzheimer's diseases, along with conditions related to cerebral ischemia. Its hepatoprotective qualities, primarily due to its anti-oxidant and tissue-regenerating properties, are well-established. Silymarin also enhances health by modifying processes such as inflammation, beta-amyloid accumulation, cellular estrogenic receptor mediation, and apoptotic machinery. While believed to reduce oxidative stress and support neuroprotective mechanisms, these effects represent just one aspect of the compound's multifaceted protective action. This review article further delves into the possibilities of potential therapeutic advancement of silymarin and silibinin for the management of neurodegenerative disorders via mechanics modules.

引用

页数：17

共 174 条

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