Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation (osteosarcomatous and chondrosarcomatous differentiation)-A Case Report and Comprehensive Review

被引：0
作者：
Rao, Meenakshi [1 ]
Anju, G. [1 ]
Navriya, Shiv Charan [2 ]
Sureka, Binit [3 ]
Kudunthail, Jeena Raju [2 ]
机构：
[1] All India Inst Med Sci, Dept Pathol & Lab Med, Jodhpur, Rajasthan, India
[2] All India Inst Med Sci, Dept Urol, Jodhpur, Rajasthan, India
[3] All India Inst Med Sci, Dept Diagnost & Intervent Radiol, Jodhpur, Rajasthan, India
来源：
JOURNAL OF KIDNEY CANCER AND VHL | 2024年 / 11卷 / 03期
关键词：
chondrosarcomatous differentiation; chromophobe; osteosarcomatous differentiation; renal cell carcinoma; TUMORS;
D O I：
10.15586/jkcvhl.v11i3.343
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromophobe renal cell carcinomas (ChRCCs) have a good prognosis and comprise approximately 5-7% of renal cell carcinomas (RCCs). The sarcomatoid differentiation in RCC is found in around 5-10% of cases; however, in ChRCC, it is much less than in other RCCs and poorly responds to chemotherapeutic agents. A study by de Peralta-Venturina et al. found 9% sarcomatoid differentiation in chromophobe RCC. We present the case of a 58-year-old female with a left abdominal mass diagnosed as ChRCC with the existence of sarcomatous differentiation including osteosarcomatous and chondrosarcomatous, which are of adverse prognosis. Osteosarcoma-like divergent differentiation in RCC is extremely rare, with limited documented cases. It should be carefully considered in evaluating and managing renal masses due to its potential impact on clinical outcomes.
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收藏
页码：59 / 64
页数：6
相关论文
共 23 条
[1]   Chromophobe renal cell carcinoma with sarcomatoid and heterologous osteosarcoma-like differentiation: a case report and literature review [J].
Abuorouq, Saleh ;
Sahawneh, Firas ;
Halalsheh, Omar ;
Haddad, Husam K. ;
Mekail, Raed ;
Alzoubi, Hiba ;
Alrjoub, Mo'ath ;
Serhan, Hashem A. .
JOURNAL OF SURGICAL CASE REPORTS, 2023, 2023 (08)
[2]   Sarcomatoid renal cell carcinoma: The chromophobe connection [J].
Akhtar, M ;
Tulbah, A ;
Kardar, AH ;
Ali, MA .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1997, 21 (10) :1188-1195
[3]  
[Anonymous], National Comprehensive Cancer Guidelines (Version 2.2005)
[4]   Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma [J].
Bi, Mark ;
Zhao, Siming ;
Said, Jonathan W. ;
Merino, Maria J. ;
Adeniran, Adebowale J. ;
Xie, Zuoquan ;
Nawaf, Cayce B. ;
Choi, Jaehyuk ;
Belldegrun, Arie S. ;
Pantuck, Allan J. ;
Kluger, Harriet M. ;
Bilguevar, Kaya ;
Lifton, Richard P. ;
Shuch, Brian .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (08) :2170-2175
[5]   Chromophobe Renal Cell Carcinoma: The Impact of Tumor Grade on Outcome [J].
Cheville, John C. ;
Lohse, Christine M. ;
Sukov, William R. ;
Thompson, Robert Houston ;
Leibovich, Bradley C. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2012, 36 (06) :851-856
[6]   Chromophobe renal cell carcinoma: Comprehensive analysis of 104 cases from multicenter European database [J].
Cindolo, L ;
De la Taille, A ;
Schips, L ;
Zigeuner, RE ;
Ficarra, V ;
Tostain, J ;
Artibani, W ;
Gallo, A ;
Salzano, L ;
Patard, JJ .
UROLOGY, 2005, 65 (04) :681-686
[7]   Sarcomatoid differentiation in renal cell carcinoma - A study of 101 cases [J].
de Peralta-Venturina, M ;
Moch, H ;
Amin, M ;
Tamboli, P ;
Hailemariam, S ;
Mihatsch, M ;
Javidan, J ;
Stricker, H ;
Ro, JY ;
Amin, MB .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (03) :275-284
[8]   Sarcomatoid renal cell carcinoma: Biology and treatment advances [J].
El Mouallem, Nemer ;
Smith, Steven C. ;
Paul, Asit K. .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2018, 36 (06) :265-271
[9]   Dedifferentiated Chromophobe Renal Cell Carcinoma With Massive Osteosarcoma-Like Divergent Differentiation: A Singular Entity in the Spectrum of Retroperitoneal Calcifying Tumors [J].
Gira, Federica A. ;
Barbieri, Antonio ;
Fellegara, Giovanni ;
Zompatori, Maurizio ;
Corradi, Domenico .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2010, 18 (05) :419-423
[10]   Metastatic sarcomatoid renal cell carcinoma treated with immune checkpoint inhibitors [J].
Hanif, Ahmad ;
Pandey, Manu ;
Khan, Sumera ;
Attwood, Kristopher ;
George, Saby .
ONCOIMMUNOLOGY, 2019, 8 (08)
123