Lactiplantibacillus plantarum P470 Isolated from Fermented Chinese Chives Has the Potential to Improve In Vitro the Intestinal Microbiota and Biological Activity in Feces of Coronary Heart Disease (CHD) Patients

被引：1

作者：

Yang, Lingshuang ^{[1
,2
]}

Wu, Yuwei ^{[2
]}

Yang, Juan ^{[3
]}

Li, Ying ^{[2
]}

Zhao, Xinyu ^{[2
]}

Liang, Tingting ^{[2
]}

Li, Longyan ^{[2
]}

Jiang, Tong ^{[2
]}

Zhang, Tiantian ^{[2
]}

Zhang, Jumei ^{[2
]}

Zhong, Haojie ^{[3
]}

Xie, Xinqiang ^{[2
]}

Wu, Qingping ^{[1
,2
]}

机构：

[1] South China Agr Univ, Coll Food Sci, Guangzhou 510642, Peoples R China

[2] Guangdong Acad Sci, Guangdong Prov Key Lab Microbial Safety & Hlth, State Key Lab Appl Microbiol Southern China, Inst Microbiol,Natl Hlth Commiss Sci & Technol Inn, Guangzhou 510070, Peoples R China

[3] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Sch Clin Med, Guangzhou 510060, Peoples R China

来源：

NUTRIENTS | 2024年 / 16卷 / 17期

关键词：

Lactiplantibacillus plantarum P470; fermented Chinese chives; intestinal microbiota; biological activity; coronary heart disease (CHD); CHAIN FATTY-ACIDS; GUT MICROBIOTA; FAILURE; OBESITY; UPDATE;

D O I：

10.3390/nu16172945

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Traditional fermented foods are known to offer cardiovascular health benefits. However, the potential of fermented Chinese chives (FCC) in reducing coronary heart disease (CHD) remains unclear. This study employed anaerobic fermentation to investigate Lactiplantibacillus plantarum (L. plantarum) P470 from FCC. The results indicated that L. plantarum P470 enhanced hydroxyl radical scavenging and exhibited anti-inflammatory effects on RAW264.7 macrophages in the fecal fermentation supernatant of CHD patients. These effects were attributed to the modulation of gut microbiota and metabolites, including short-chain fatty acids (SCFAs). Specifically, L. plantarum P470 increased the abundance of Bacteroides and Lactobacillus while decreasing Escherichia-Shigella, Enterobacter, Veillonella, Eggerthella, and Helicobacter in CHD patient fecal samples. Furthermore, L. plantarum P470 regulated the biosynthesis of unsaturated fatty acids and linoleic acid metabolism. These findings suggest that L. plantarum P470 from FCC can improve the fecal physiological status in patients with CHD by modulating intestinal microbiota, promoting SCFA production, and regulating lipid metabolism.

引用

页数：18