The Epigenetic Hallmarks of Cancer

被引：45

作者：

Esteller, Manel ^{[1
,2
,3
,4
]}

Dawson, Mark A. ^{[5
,6
,7
]}

Kadoch, Cigall ^{[8
,9
,10
,11
]}

Rassool, Feyruz V. ^{[12
,13
]}

Jones, Peter A. ^{[14
]}

Baylin, Stephen B. ^{[14
,15
]}

机构：

[1] Josep Carreras Leukaemia Res Inst IJC, Canc Epigenet Grp, Barcelona, Spain

[2] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[3] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain

[4] Univ Barcelona UB, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona, Spain

[5] Peter MacCallum Canc Ctr, Melbourne, Australia

[6] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Australia

[7] Univ Melbourne, Ctr Canc Res, Melbourne, Australia

[8] Dana Farber Canc Inst, Boston, MA USA

[9] Harvard Med Sch, Boston, MA USA

[10] Broad Inst MIT & Harvard, Cambridge, MA USA

[11] Howard Hughes Med Inst, Chevy Chase, MD USA

[12] Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Comprehens Canc Ctr, Baltimore, MD USA

[13] Univ Maryland, Sch Med, Dept Radiat Oncol, Baltimore, MD USA

[14] Van Andel Inst, Dept Epigenet, Grand Rapids, MI USA

[15] Sidney Kimmel Comprehens Canc Ctr, Johns Hopkins Sch Med, Dept Oncol, Baltimore, MD USA

来源：

CANCER DISCOVERY | 2024年 / 14卷 / 10期

基金：

美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会;

关键词：

CELL LUNG-CANCER; GROUP PROTEIN EZH2; GENE O-6-METHYLGUANINE-DNA METHYLTRANSFERASE; HMLH1 PROMOTER HYPERMETHYLATION; CPG ISLAND HYPERMETHYLATION; HEMATOPOIETIC STEM-CELLS; ABERRANT DNA METHYLATION; TUMOR-SUPPRESSOR GENES; SOMATIC MUTATIONS; SYNTHETIC LETHAL;

D O I：

10.1158/2159-8290.CD-24-0296

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a complex disease in which several molecular and cellular pathways converge to foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks, "nonmutational epigenetic reprogramming" was newly added. However, epigenetics, much like genetics, is a broad scientific area that deserves further attention due to its multiple roles in cancer initiation, progression, and adaptive nature. Herein, we present a detailed examination of the epigenetic hallmarks affected in human cancer, elucidating the pathways and genes involved, and dissecting the disrupted landscapes for DNA methylation, histone modifications, and chromatin architecture that define the disease.Significance: Cancer is a disease characterized by constant evolution, spanning from its initial premalignant stages to the advanced invasive and disseminated stages. It is a pathology that is able to adapt and survive amidst hostile cellular microenvironments and diverse treatments implemented by medical professionals. The more fixed setup of the genetic structure cannot fully provide transformed cells with the tools to survive but the rapid and plastic nature of epigenetic changes is ready for the task. This review summarizes the epigenetic hallmarks that define the ecological success of cancer cells in our bodies.

引用

页码：1783 / 1809

页数：27

共 309 条

[1] Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature [J].

Abu-Hanna, Jeries ;

Patel, Jigisha A. ;

Anastasakis, Evangelos ;

Cohen, Richard ;

Clapp, Lucie H. ;

Loizidou, Marilena ;

Eddama, Mohammad M. R. .

CLINICAL EPIGENETICS, 2022, 14 (01)

[2] Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma [J].

Agarwal, Rishu ;

Chan, Yih-Chih ;

Tam, Constantine S. ;

Hunter, Tane ;

Vassiliadis, Dane ;

Teh, Charis E. ;

Thijssen, Rachel ;

Yeh, Paul ;

Wong, Stephen Q. ;

Ftouni, Sarah ;

Lam, Enid Y. N. ;

Anderson, Mary Ann ;

Pott, Christiane ;

Gilan, Omer ;

Bell, Charles C. ;

Knezevic, Kathy ;

Blombery, Piers ;

Rayeroux, Kathleen ;

Zordan, Adrian ;

Li, Jason ;

Huang, David C. S. ;

Wall, Meaghan ;

Seymour, John F. ;

Gray, Daniel H. D. ;

Roberts, Andrew W. ;

Dawson, Mark A. ;

Dawson, Sarah-Jane .

NATURE MEDICINE, 2019, 25 (01) :119-+

[3] Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts [J].

Albrengues, Jean ;

Bertero, Thomas ;

Grasset, Eloise ;

Bonan, Stephanie ;

Maiel, Majdi ;

Bourget, Isabelle ;

Philippe, Claude ;

Serrano, Cecilia Herraiz ;

Benamar, Samia ;

Croce, Olivier ;

Sanz-Moreno, Victoria ;

Meneguzzi, Guerrino ;

Feral, Chloe C. ;

Cristofari, Gael ;

Gaggioli, Cedric .

NATURE COMMUNICATIONS, 2015, 6

[4] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[5] Toward understanding and exploiting tumor heterogeneity [J].

Alizadeh, Ash A. ;

Aranda, Victoria ;

Bardelli, Alberto ;

Blanpain, Cedric ;

Bock, Christoph ;

Borowski, Christine ;

Caldas, Carlos ;

Califano, Andrea ;

Doherty, Michael ;

Elsner, Markus ;

Esteller, Manel ;

Fitzgerald, Rebecca ;

Korbel, Jan O. ;

Lichter, Peter ;

Mason, Christopher E. ;

Navin, Nicholas ;

Pe'er, Dana ;

Polyak, Kornelia ;

Roberts, Charles W. M. ;

Siu, Lillian ;

Snyder, Alexandra ;

Stower, Hannah ;

Swanton, Charles ;

Verhaak, Roel G. W. ;

Zenklusen, Jean C. ;

Zuber, Johannes ;

Zucman-Rossi, Jessica .

NATURE MEDICINE, 2015, 21 (08) :846-853

[6] A gene-environment-induced epigenetic program initiates tumorigenesis [J].

Alonso-Curbelo, Direna ;

Ho, Yu-Jui ;

Burdziak, Cassandra ;

Maag, Jesper L. V. ;

Morris, John P. ;

Chandwani, Rohit ;

Chen, Hsuan-An ;

Tsanov, Kaloyan M. ;

Barriga, Francisco M. ;

Luan, Wei ;

Tasdemir, Nilgun ;

Livshits, Geulah ;

Azizi, Elham ;

Chun, Jaeyoung ;

Wilkinson, John E. ;

Mazutis, Linas ;

Leach, Steven D. ;

Koche, Richard ;

Pe'er, Dana ;

Lowe, Scott W. .

NATURE, 2021, 590 (7847) :642-648

[7] Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair [J].

Alvarez, Silvia ;

Almeida, Ana C. da Silva ;

Albero, Robert ;

Biswas, Mayukh ;

Barreto-Galvez, Angelica ;

Gunning, Thomas S. ;

Shaikh, Anam ;

Aparicio, Tomas ;

Wendorff, Agnieszka ;

Piovan, Erich ;

Van Vlierberghe, Pieter ;

Gygi, Steven ;

Gautier, Jean ;

Madireddy, Advaitha ;

Ferrando, Adolfo A. .

BLOOD, 2022, 139 (23) :3418-3429

[8] Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma [J].

An, Shejuan ;

Camarillo, Jeannie M. ;

Huang, Tina Yi-Ting ;

Li, Daphne ;

Morris, Juliette A. ;

Zoltek, Madeline A. ;

Qi, Jin ;

Behbahani, Mandana ;

Kambhampati, Madhuri ;

Kelleher, Neil L. ;

Nazarian, Javad ;

Thomas, Paul M. ;

Saratsis, Amanda M. .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)

[9] Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia [J].

Anadon, C. ;

van Tetering, G. ;

Ferreira, H. J. ;

Moutinho, C. ;

Martinez-Cardus, A. ;

Villanueva, A. ;

Soler, M. ;

Heyn, H. ;

Moran, S. ;

Castro de Moura, M. ;

Setien, F. ;

Vidal, A. ;

Genesc, E. ;

Ribera, J. M. ;

Nomdedeu, J. F. ;

Guil, S. ;

Esteller, M. .

LEUKEMIA, 2017, 31 (07) :1622-1625

[10] Oncohistones in brain tumors: the soil and seed [J].

Andrade, Augusto Faria ;

Chen, Carol C. L. ;

Jabado, Nada .

TRENDS IN CANCER, 2023, 9 (05) :444-455

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