Diagnosis, management and follow-up of follicular lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance

被引:2
作者
Tobin, Joshua W. D. [1 ,2 ]
Hapgood, Greg [1 ,2 ]
Johnston, Anna [4 ]
Cheah, Chan Y. [5 ,6 ]
Lee, Sze T. [7 ,8 ]
Trotman, Judith [11 ,12 ]
Inam, Shafqat [9 ]
Campbell, Belinda A. [8 ,10 ]
Norris, Debbie [3 ]
MacManus, Michael [8 ,10 ]
Hertzberg, Mark [12 ,13 ]
Hawkes, Eliza [7 ,8 ]
机构
[1] Princess Alexandra Hosp, Brisbane, Qld, Australia
[2] Univ Queensland, Brisbane, Qld, Australia
[3] QML Pathol, Brisbane, Qld, Australia
[4] Royal Hobart Hosp, Hobart, Tas, Australia
[5] Sir Charles Gairdner Hosp, Perth, WA, Australia
[6] Univ Western Australia, Perth, WA, Australia
[7] Austin Hlth, Melbourne, Vic, Australia
[8] Univ Melbourne, Melbourne, Vic, Australia
[9] Alfred Hlth, Melbourne, Vic, Australia
[10] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
[11] Concord Repatriat Gen Hosp, Sydney, NSW, Australia
[12] Univ Sydney, Sydney, NSW, Australia
[13] Prince Wales Hosp, Sydney, NSW, Australia
关键词
follicular lymphoma; diagnosis; staging; radiotherapy; chemotherapy; maintenance; STEM-CELL TRANSPLANTATION; NON-HODGKIN-LYMPHOMA; 1ST-LINE TREATMENT; ADVANCED-STAGE; RANDOMIZED-TRIAL; OPEN-LABEL; AUTOLOGOUS TRANSPLANTATION; RITUXIMAB MAINTENANCE; RESPONSE ASSESSMENT; RADIATION-THERAPY;
D O I
10.1111/imj.16454
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma subtype, accounting for 15-20% of all lymphoma diagnoses. Although typically slow-growing and responsive to frontline therapies, advanced-stage FL remains incurable with current treatments and typically follows a chronic relapsing/remitting course with increasingly shorter responses to subsequent lines of therapy. Outcomes are highly variable; some patients experience prolonged first remissions that may approximate a 'functional cure'. By contrast, a significant minority of patients experience disease progression shortly after frontline treatment resulting in high rates of lymphoma-related mortality. Reflecting on the heterogeneous natural history of FL, clinical practice varies widely, particularly in controversial areas, including appropriate disease staging, selection of management strategies and duration of clinical follow-up. This position statement presents an evidence-based synthesis of the literature for application in Australasian practice.
引用
收藏
页码:1384 / 1395
页数:12
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