A New Phase for WNK Kinase Signaling Complexes as Biomolecular Condensates

被引：2

作者：

Boyd-Shiwarski, Cary R. ^{[1
,2
]}

Shiwarski, Daniel J. ^{[3
,4
]}

Subramanya, Arohan R. ^{[1
,2
,5
,6
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med, Renal Electrolyte Div, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Pittsburgh Heart Lung Blood Vasc Med Inst, Sch Med, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Vasc Med Inst, Sch Med, Dept Med, Pittsburgh, PA USA

[4] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA

[5] Univ Pittsburgh, Dept Cell Biol, Pittsburgh, PA USA

[6] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA

来源：

PHYSIOLOGY | 2024年 / 39卷 / 05期

基金：

美国国家卫生研究院;

关键词：

biomolecular condensates; phase separation; WNK bodies; WNK droplets; WNK kinases; BLOOD-PRESSURE; STRESS GRANULES; PROTEIN-KINASE; LIQUID DROPLETS; SEPARATION; GENE; HYPERTENSION; TRANSITION; EXPRESSION; POTASSIUM;

D O I：

10.1152/physiol.00013.2024

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The purpose of this review is to highlight transformative advances that have been made in the field of biomolecular condensates, with special emphasis on condensate material properties, physiology, and kinases, using the With-No-Lysine (WNK) kinases as a prototypical example. To convey how WNK kinases illustrate important concepts for biomolecular condensates, we start with a brief history, focus on defining features of biomolecular condensates, and delve into some examples of how condensates are implicated in cellular physiology (and pathophysiology). We then highlight how WNK kinases, through the action of "WNK droplets" that ubiquitously regulate intracellular volume and kidney-specific "WNK bodies" that are implicated in distal tubule salt reabsorption and potassium homeostasis, exemplify many of the defining features of condensates. Finally, this review addresses the controversies within this emerging field and questions to address.

引用

页码：269 / 287

页数：19

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