Membrane-camouflaged biomimetic nanoplatform with arsenic complex for synergistic reinforcement of liver cancer therapy

被引：3

作者：

Wang, Shu ^{[1
]}

Su, Yupei ^{[1
]}

Li, Jiayang ^{[1
]}

Wang, Tianyi ^{[1
]}

Pan, Hao ^{[2
,3
]}

Pan, Weisan ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China

[2] Liaoning Univ, Shenyang 110036, Peoples R China

[3] Key Lab Key Technol Res & Evaluat Chem Drug Qual C, Shenyang, Liaoning, Peoples R China

来源：

NANOMEDICINE | 2024年 / 19卷 / 26期

基金：

中国国家自然科学基金;

关键词：

hepatocarcinoma targeting therapy; immunomodulation; M1 macrophage membrane; manganese-arsenic complex; mesoporous polydopamine; MACROPHAGE CELL-MEMBRANE; DELIVERY-SYSTEM; POLYDOPAMINE NANOPARTICLES; M2-POLARIZED MACROPHAGES; TUMOR; NANOCARRIERS; INHIBITION; TRIOXIDE;

D O I：

10.1080/17435889.2024.2393076

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Arsenic has excellent anti-advanced liver cancer effects through a variety of pathways, but its severe systemic toxicity forces the need for a safe and effective delivery strategy. Methods: Based on the chelating metal ion properties of polydopamine (PDA), arsenic was immobilized on an organic carrier, and a M1-like macrophage cell membrane (MM)-camouflaged manganese-arsenic complex mesoporous polydopamine (MnAsOx@MP@M) nanoplatform was successfully constructed. MnAsOx@MP@M was evaluated at the cellular level for tumor inhibition and tumor localization, and in vivo for its anti-liver cancer effect in a Hepa1-6 tumor-bearing mouse model. Results: The nanoplatform targeted the tumor site through the natural homing property of MM, completely degraded and released drugs to kill tumor cells in an acidic environment, while playing an immunomodulatory role in promoting tumor-associated macrophages (TAMs) repolarization. Conclusion: MnAsOx@MP@M has synergistically enhanced the targeted therapeutics against liver cancer via nanotechnology and immunotherapy, and it is expected to become a safe and multifunctional treatment platform in clinical oncology.

引用

页码：2187 / 2210

页数：24

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