Non-Invasive Serum Markers of Non-Alcoholic Fatty Liver Disease Fibrosis: Potential Tools for Detecting Patients with Cardiovascular Disease

被引：1

作者：

Chen, Ling-Zi ^{[1
]}

Jing, Xu-Bin ^{[1
]}

Chen, Xiang ^{[1
]}

Xie, Yan-Chun ^{[2
]}

Chen, Yun ^{[1
]}

Cai, Xian-Bin ^{[1
]}

机构：

[1] Shantou Univ, Affiliated Hosp 1, Dept Gastroenterol, Med Coll, Shantou 515041, Guangdong, Peoples R China

[2] Shantou Univ, Dept Endoscopy Ctr, Canc Hosp, Med Coll, Shantou 515041, Guangdong, Peoples R China

来源：

REVIEWS IN CARDIOVASCULAR MEDICINE | 2024年 / 25卷 / 09期

关键词：

biomarkers; cardiovascular disease; fibrosis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; MAGNETIC-RESONANCE ELASTOGRAPHY; CORONARY-ARTERY-DISEASE; 8-ISO-PROSTAGLANDIN F2-ALPHA; OXIDATIVE STRESS; XL PROBE; ASSOCIATION; STEATOHEPATITIS; BIOPSY; RISK; MORTALITY;

D O I：

10.31083/j.rcm2509344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD), one of the most common chronic liver diseases with a prevalence of 23%-25% globally, is an independent risk factor for cardiovascular diseases (CVDs). Growing evidence indicates that the development of NAFLD, ranging from non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), advanced fibrosis to cirrhosis, and even hepatocellular carcinoma, is at substantial risk for CVDs, which clinically contribute to increased cardiovascular morbidity and mortality. Non-invasive serum markers assessing liver fibrosis, such as fibrosis-4 (FIB-4) score, aspartate transaminase-to-platelet ratio index (APRI), and NAFLD fibrosis score (NFS), are expected to be useful tools for clinical management of patients with CVDs. This review aims to provide an overview of the evidence for the relationship between the progression of NAFLD and CVDs and the clinical application of non-invasive markers of liver fibrosis in managing patients with CVDs.

引用

页数：11

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