Non-Invasive Serum Markers of Non-Alcoholic Fatty Liver Disease Fibrosis: Potential Tools for Detecting Patients with Cardiovascular Disease

被引：1

作者：

Chen, Ling-Zi ^{[1
]}

Jing, Xu-Bin ^{[1
]}

Chen, Xiang ^{[1
]}

Xie, Yan-Chun ^{[2
]}

Chen, Yun ^{[1
]}

Cai, Xian-Bin ^{[1
]}

机构：

[1] Shantou Univ, Affiliated Hosp 1, Dept Gastroenterol, Med Coll, Shantou 515041, Guangdong, Peoples R China

[2] Shantou Univ, Dept Endoscopy Ctr, Canc Hosp, Med Coll, Shantou 515041, Guangdong, Peoples R China

来源：

REVIEWS IN CARDIOVASCULAR MEDICINE | 2024年 / 25卷 / 09期

关键词：

biomarkers; cardiovascular disease; fibrosis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; MAGNETIC-RESONANCE ELASTOGRAPHY; CORONARY-ARTERY-DISEASE; 8-ISO-PROSTAGLANDIN F2-ALPHA; OXIDATIVE STRESS; XL PROBE; ASSOCIATION; STEATOHEPATITIS; BIOPSY; RISK; MORTALITY;

D O I：

10.31083/j.rcm2509344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD), one of the most common chronic liver diseases with a prevalence of 23%-25% globally, is an independent risk factor for cardiovascular diseases (CVDs). Growing evidence indicates that the development of NAFLD, ranging from non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), advanced fibrosis to cirrhosis, and even hepatocellular carcinoma, is at substantial risk for CVDs, which clinically contribute to increased cardiovascular morbidity and mortality. Non-invasive serum markers assessing liver fibrosis, such as fibrosis-4 (FIB-4) score, aspartate transaminase-to-platelet ratio index (APRI), and NAFLD fibrosis score (NFS), are expected to be useful tools for clinical management of patients with CVDs. This review aims to provide an overview of the evidence for the relationship between the progression of NAFLD and CVDs and the clinical application of non-invasive markers of liver fibrosis in managing patients with CVDs.

引用

页数：11

共 91 条

[1] Association Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease Complexity in Patients With Acute Coronary Syndrome: A Pilot Study [J].

Agac, Mustafa Tarik ;

Korkmaz, Levent ;

Cavusoglu, Goekhan ;

Karadeniz, Ayse Gul ;

Agac, Suret ;

Bektas, Huseyin ;

Erkan, Hakan ;

Varol, Mustafa Oguz ;

Vatan, Mehmet Bulent ;

Acar, Zeydin ;

Mentese, Umit ;

Celik, Sukrue .

ANGIOLOGY, 2013, 64 (08) :604-608

[2] Fatty liver disease in severe obese patients: Diagnostic value of abdominal ultrasound [J].

Almeida, Alessandro de Moura ;

Cotrim, Helma Pinchemel ;

Valente Barbosa, Daniel Batista ;

Matteoni de Athayde, Luciana Gordilho ;

Santos, Adimeia Souza ;

Vieira Bitencourt, Almir Galvo ;

Rodrigues de Freitas, Luiz Antonio ;

Rios, Adriano ;

Alves, Erivaldo .

WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (09) :1415-1418

[3] The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD [J].

Angulo, Paul ;

Hui, Jason M. ;

Marchesini, Giulio ;

Bugianesi, Ellisabetta ;

George, Jacob ;

Farrell, Geoffrey C. ;

Enders, Felicity ;

Saksena, Sushma ;

Burt, Alastair D. ;

Bida, John P. ;

Lindor, Keith ;

Sanderson, Schuyler O. ;

Lenzi, Marco ;

Adams, Leon A. ;

Kench, James ;

Therneau, Terry M. ;

Day, Christopher P. .

HEPATOLOGY, 2007, 45 (04) :846-854

[4] Simple Noninvasive Systems Predict Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease [J].

Angulo, Paul ;

Bugianesi, Elisabetta ;

Bjornsson, Einar S. ;

Charatcharoenwitthaya, Phunchai ;

Mills, Peter R. ;

Barrera, Francisco ;

Haflidadottir, Svanhildur ;

Day, Christopher P. ;

George, Jacob .

GASTROENTEROLOGY, 2013, 145 (04) :782-+

[5] Nonalcoholic Fatty Liver Disease and Fibrosis Associated With Increased Risk of Cardiovascular Events in a Prospective Study [J].

Baratta, Francesco ;

Pastori, Daniele ;

Angelico, Francesco ;

Balla, Andrea ;

Paganini, Alessandro Maria ;

Cocomello, Nicholas ;

Ferro, Domenico ;

Violi, Francesco ;

Sanyal, Arun J. ;

Del Ben, Maria .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 18 (10) :2324-+

[6] EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update [J].

Berzigotti, Annalisa ;

Tsochatzis, Emmanouil ;

Boursier, Jerome ;

Castera, Laurent ;

Cazzagon, Nora ;

Friedrich-Rust, Mireen ;

Petta, Salvatore ;

Thiele, Maja .

JOURNAL OF HEPATOLOGY, 2021, 75 (03) :659-689

[7] The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis [J].

Bohte, Anneloes E. ;

van Werven, Jochem R. ;

Bipat, Shandra ;

Stoker, Jaap .

EUROPEAN RADIOLOGY, 2011, 21 (01) :87-97

[8] The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases [J].

Brown, J. Mark ;

Hazen, Stanley L. .

ANNUAL REVIEW OF MEDICINE, VOL 66, 2015, 66 :343-359

[9] Increasing Liver Fat Is Associated With Incident Cardiovascular Risk Factors [J].

Brunner, Katherine T. ;

Pedley, Alison ;

Massaro, Joseph M. ;

Hoffmann, Udo ;

Benjamin, Emelia J. ;

Long, Michelle T. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 18 (08) :1884-1886

[10] Prognostic impact of liver fibrosis and steatosis by transient elastography for cardiovascular and mortality outcomes in individuals with nonalcoholic fatty liver disease and type 2 diabetes: the Rio de Janeiro Cohort Study [J].

Cardoso, Claudia R. L. ;

Villela-Nogueira, Cristiane A. ;

Leite, Nathalie C. ;

Salles, Gil F. .

CARDIOVASCULAR DIABETOLOGY, 2021, 20 (01)

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