1,3,4-Oxadiazole and Its Analogs: Recently Adopted Synthetic Approaches and Interaction with Targets

被引：0

作者：

Kumar, Greesh ^{[1
]}

Kumar, Rajnish ^{[1
]}

Mazumder, Avijit ^{[1
]}

Kumar, Upendra ^{[1
]}

机构：

[1] Noida Inst Engn & Technol, Pharm Inst, Dept Pharmaceut Chem, Greater Noida, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2024年 / 21卷 / 12期

关键词：

1,3,4-oxadiazole; patents; marketed drugs; therapeutic activities; synthetic approaches; target interactions; ONE-POT SYNTHESIS; 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES; MOLECULAR ASSOCIATION; ALKALINE-PHOSPHATASE; THYMIDYLATE SYNTHASE; BIOLOGICAL-ACTIVITY; EFFICIENT SYNTHESIS; DERIVATIVES; ACID; DESIGN;

D O I：

10.2174/1570180820666230701000317

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,3,4-Oxadiazole is a five-membered heterocyclic compound with one oxygen, two nitrogen, and two carbon atoms arranged in a ring. Several research reports, patents, and marketed drugs have already established 1,3,4-oxadiazole and its analog as potential molecules having a diverse range of pharmacological activities. In this review, we focused on recently acknowledged straightforward synthesis approaches for 1,3,4-oxadiazole and its analogs. Additionally, interactions of the 1,3,4-oxadiazole derivative with different biological targets (enzymes and receptors) have been described. The present findings discussed in this review analysis will aid researchers in conducting future research on 1,3,4-oxadiazole.

引用

页码：2335 / 2351

页数：17

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