Iodine Mediated Annulation of Triethylamine, Aldehydes and 2-Aminopyridines for the Synthesis of 3-Formyl-Imidazo [1,2-a]pyridine Derivatives

被引：2

作者：

Zhang, Wenqing ^{[1
]}

Shen, Lihong ^{[2
]}

Zhang, Jun ^{[1
]}

机构：

[1] Ningxia Univ, Coll Chem & Chem Engn, Yinchuan 750021, Ningxia, Peoples R China

[2] Handan Univ, Hebei Key Lab Heterocycl Cpds, Handan 056005, Hebei, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 18期

关键词：

heterocycle; formylation; iodine; triethylamine; annulation; TERTIARY-AMINES; FORMYLATION;

D O I：

10.1002/adsc.202400473

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

With triethylamine as a synthon, an alternative method for the synthesis of 3-formyl imidazo[1,2-a]pyridines has been accomplished from aldehydes, and 2-aminopyridines. The reaction proceeded via iodine-catalyzed C-N bond cleavage of triethylamine, generation of alpha,beta-unsaturated aldehyde in situ, and oxidative cyclization with air as the oxygen source. This protocol may facilitate the synthesis of imidazo[1,2-a]pyridine derivatives and provide a reference for the usage of triethylamine as a synthon. image

引用

页码：3796 / 3801

页数：6

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