Iodine Mediated Annulation of Triethylamine, Aldehydes and 2-Aminopyridines for the Synthesis of 3-Formyl-Imidazo [1,2-a]pyridine Derivatives

被引：2
作者：
Zhang, Wenqing [1 ]
Shen, Lihong [2 ]
Zhang, Jun [1 ]
机构：
[1] Ningxia Univ, Coll Chem & Chem Engn, Yinchuan 750021, Ningxia, Peoples R China
[2] Handan Univ, Hebei Key Lab Heterocycl Cpds, Handan 056005, Hebei, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 18期
关键词：
heterocycle; formylation; iodine; triethylamine; annulation; TERTIARY-AMINES; FORMYLATION;
D O I：
10.1002/adsc.202400473
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
With triethylamine as a synthon, an alternative method for the synthesis of 3-formyl imidazo[1,2-a]pyridines has been accomplished from aldehydes, and 2-aminopyridines. The reaction proceeded via iodine-catalyzed C-N bond cleavage of triethylamine, generation of alpha,beta-unsaturated aldehyde in situ, and oxidative cyclization with air as the oxygen source. This protocol may facilitate the synthesis of imidazo[1,2-a]pyridine derivatives and provide a reference for the usage of triethylamine as a synthon. image
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收藏
页码：3796 / 3801
页数：6
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