NHC catalyzed radical tandem cyclization: an efficient synthesis of α,α-difluoro-γ-lactam derivatives

被引：1

作者：

Huang, Tianjiao ^{[1
]}

Yin, Huiping ^{[1
]}

Li, Tuanjie ^{[1
]}

Yu, Chenxia ^{[1
]}

Zhang, Kai ^{[1
]}

Yao, Changsheng ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 34期

基金：

中国国家自然科学基金;

关键词：

AMINODIFLUOROALKYLATION; LACTAMS; ACID;

D O I：

10.1039/d4ob01012d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, an N-heterocyclic carbene (NHC) catalyzed radical tandem cyclization reaction of N-allylbromodifluoroacetamides and aldehydes has been developed. This method is an efficient protocol for synthesizing alpha,alpha-difluoro-gamma-lactam derivatives in moderate to good yields (27 examples, up to 88% yield and 10 : 1 dr). This strategy features mild and metal-free conditions, high efficiency, and a broad substrate scope. An N-heterocyclic carbene catalyzed radical tandem cyclization reaction of N-allylbromodifluoroacetamides and aldehydes has been developed. This method provides a protocol for synthesizing alpha,alpha-difluoro-gamma-lactam derivatives in moderate to good results (27 examples, up to 88% yield, 10 : 1 d.r.).

引用

页码：6988 / 6998

页数：11

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