Informing Endpoints for Clinical Trials of Geographic Atrophy

被引：4

作者：

Lad, Eleonora M. ^{[1
]}

Fleckenstein, Monika ^{[2
]}

Holz, Frank G. ^{[3
]}

Shen, Liangbo ^{[4
]}

Del Priore, Lucian V. ^{[5
]}

Silva, Rufino ^{[6
,7
,8
,9
]}

Staurenghi, Giovanni ^{[10
]}

Waheed, Nadia ^{[11
]}

Chakravarthy, Usha ^{[12
]}

机构：

[1] Duke Univ, Med Ctr, Dept Ophthalmol, Durham, NC 27710 USA

[2] Univ Utah, John A Moran Eye Ctr, Dept Ophthalmol & Visual Sci, Salt Lake City, UT USA

[3] Univ Bonn, Dept Ophthalmol, Bonn, Germany

[4] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA

[5] Yale Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT USA

[6] Univ Coimbra FMUC, Fac Med, Coimbra, Portugal

[7] Coimbra Hosp & Univ Ctr CHUC, Dept Ophthalmol, Coimbra, Portugal

[8] Clin Acad Ctr Coimbra CACC, Coimbra, Portugal

[9] Assoc Innovat & Biomed Res Light & Image AIBILI, Coimbra, Portugal

[10] Univ Milan, Luigi Sacco Hosp, Dept Biomed & Clin Sci, Milan, Italy

[11] Tufts Med Ctr, Boston, MA USA

[12] Queens Univ, Ctr Publ Hlth, Dept Ophthalmol, Belfast, Antrim, North Ireland

来源：

ANNUAL REVIEW OF VISION SCIENCE | 2024年 / 10卷

基金：

美国国家卫生研究院;

关键词：

geographic atrophy; structural endpoints; functional endpoints; microperimetry; low-luminance; visual acuity; reading speed; age-related macular degeneration; COHERENCE TOMOGRAPHY ANGIOGRAPHY; SUBFOVEAL CHOROIDAL THICKNESS; VISUAL-ACUITY LOSS; MACULAR DEGENERATION; NATURAL-HISTORY; FUNDUS AUTOFLUORESCENCE; RETICULAR PSEUDODRUSEN; AVACINCAPTAD PEGOL; FIXATION PATTERNS; CENTRAL SCOTOMAS;

D O I：

10.1146/annurev-vision-101922-045110

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Geographic atrophy (GA), the non-neovascular advanced form of age-related macular degeneration, remains an important disease area in which treatment needs are currently unmet. Recent clinical trials using drugs that target the complement pathway have shown modest yet consistent reductions in GA expansion but without commensurate changes in measures of visual function. In this review, we summarize information from the wide range of studies describing the characteristics of GA morphology and enumerate the factors influencing the growth rates of lesions and the directionality of expansion. In addition, we review the relationship between GA growth and the various measures of vision that reflect changes in function. We consider the reasons for the discordance between the anatomical and functional endpoints in current use and discuss methods to align these key outcomes.

引用

页码：455 / 476

页数：22

共 85 条

[1] Vitreoretinal Interface Changes in Geographic Atrophy [J].

Abdillahi, Hannan ;

Enzmann, Volker ;

Wittwer, Valery V. ;

Wolf, Sebastian ;

Wolf-Schnurrbusch, Ute E. K. .

OPHTHALMOLOGY, 2014, 121 (09) :1734-1739

[2] ANALYSIS OF THE THICKNESS AND VASCULAR LAYERS OF THE CHOROID IN EYES WITH GEOGRAPHIC ATROPHY USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY [J].

Adhi, Mehreen ;

Lau, Marisa ;

Liang, Michelle C. ;

Waheed, Nadia K. ;

Duker, Jay S. .

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2014, 34 (02) :306-312

[3] Reticular Pseudodrusen Status, ARMS2/ HTRA1 Genotype, and Geographic Atrophy Enlargement [J].

Agron, Elvira ;

Domalpally, Amitha ;

Cukras, Catherine A. ;

Clemons, Traci E. ;

Chen, Qingyu ;

Swaroop, Anand ;

Lu, Zhiyong ;

Chew, Emily Y. ;

Keenan, Tiarnan D. L. .

OPHTHALMOLOGY, 2023, 130 (05) :488-500

[4] Adherence to a Mediterranean Diet and Geographic Atrophy Enlargement Rate Age-Related Eye Disease Study 2 Report 29 [J].

Agron, Elvira ;

Mares, Julie ;

Chew, Emily Y. ;

Keenan, Tiarnan D. L. .

OPHTHALMOLOGY RETINA, 2022, 6 (09) :762-770

[5] The influence of the topographic location of geographic atrophy on vision-related quality of life in nonexudative age-related macular degeneration [J].

Ahluwalia, Aneesha ;

Shen, Liangbo L. ;

Bao, Yihan ;

Sun, Mengyuan ;

Young, Benjamin K. ;

Park, Michael M. ;

Del Priore, Lucian, V .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2023, 261 (03) :699-708

[6] Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration [J].

Allingham, Michael J. ;

Nie, Qing ;

Lad, Eleonora M. ;

Izatt, Daniel J. ;

Mettu, Priyatham S. ;

Cousins, Scott W. ;

Farsiu, Sina .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (04) :2283-2289

[7] Visual Acuity Is Not the Best at the Preferred Retinal Locus in People with Macular Disease [J].

Bernard, Jean-Baptiste ;

Chung, Susana T. L. .

OPTOMETRY AND VISION SCIENCE, 2018, 95 (09) :829-836

[8] Increased Fundus Autofluorescence and Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration: The GAIN Study [J].

Biarnes, Marc ;

Arias, Luis ;

Alonso, Jordi ;

Garcia, Miriam ;

Hijano, Miriam ;

Rodriguez, Anabel ;

Serrano, Anna ;

Badal, Josep ;

Muhtaseb, Hussein ;

Verdaguer, Paula ;

Mones, Jordi .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2015, 160 (02) :345-353

[9] Treatment-Naive Quiescent Choroidal Neovascularization in Geographic Atrophy Secondary to Nonexudative Age-Related Macular Degeneration [J].

Capuano, Vittorio ;

Miere, Alexandra ;

Querques, Lea ;

Sacconi, Riccardo ;

Carnevali, Adriano ;

Amoroso, Francesca ;

Bandello, Francesco ;

Souied, Eric H. ;

Querques, Giuseppe .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2017, 182 :45-55

[10] Optical Coherence Tomography Angiography: A Useful Tool for Diagnosis of Treatment-Naive Quiescent Choroidal Neovascularization [J].

Carnevali, Adriano ;

Cicinelli, Maria Vittoria ;

Capuano, Vittorio ;

Corvi, Federico ;

Mazzaferro, Andrea ;

Querques, Lea ;

Scorcia, Vincenzo ;

Souied, Eric H. ;

Bandello, Francesco ;

Querques, Giuseppe .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2016, 169 :189-198

← 1 2 3 4 5 6 7 8 9 →