Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis

被引：4

作者：

Toljan, Karlo ^{[1
,2
]}

Daboul, Lynn ^{[3
,4
,5
]}

Raza, Praneeta ^{[2
]}

Martin, Melissa L. ^{[6
,7
]}

Cao, Quy ^{[6
,7
]}

O'Donnell, Carly M. ^{[6
,7
]}

Rodrigues, Paulo ^{[8
]}

Derbyshire, John ^{[9
]}

Azevedo, Christina J. ^{[10
]}

Bar-Or, Amit ^{[11
]}

Caverzasi, Eduardo ^{[12
,13
]}

Calabresi, Peter A. ^{[14
]}

Cree, Bruce A. C. ^{[12
]}

Freeman, Leorah ^{[15
]}

Henry, Roland G. ^{[12
]}

Longbrake, Erin E. ^{[16
]}

Oh, Jiwon ^{[17
]}

Papinutto, Nico ^{[12
]}

Pelletier, Daniel ^{[2
,10
]}

Samudralwar, Rohini D. ^{[11
,18
]}

Schindler, Matthew K. ^{[11
]}

Sotirchos, Elias S. ^{[14
]}

Sicotte, Nancy L. ^{[19
]}

Solomon, Andrew J. ^{[20
]}

Shinohara, Russell T. ^{[6
,7
,21
]}

Reich, Daniel S. ^{[3
]}

Sati, Pascal ^{[3
,19
]}

Ontaneda, Daniel ^{[2
]}

机构：

[1] Cleveland Clin, Neurol Inst, Dept Neurol, Cleveland, OH USA

[2] Cleveland Clin, Neurol Inst, Mellen Ctr Multiple Sclerosis Treatment & Res, 1950 E 89th St U Bldg, Cleveland, OH 44195 USA

[3] NIH, Translat Neuroradiol Sect, Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA

[4] Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA

[5] Brigham & Womens Hosp, Dept Neurol, Boston, MA USA

[6] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA USA

[7] Univ Penn, Perelman Sch Med, Penn Stat Imaging & Visualizat Endeavor, Philadelphia, PA USA

[8] QMENTA, Boston, MA USA

[9] NIH, Funct MRI Facil, Natl Inst Mental Hlth, Bethesda, MD USA

[10] Univ Southern Calif, Dept Neurol, Los Angeles, CA USA

[11] Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA USA

[12] Univ Calif San Francisco, Weill Inst Neurosci, Dept Neurol, San Francisco, CA USA

[13] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[14] Johns Hopkins Univ, Dept Neurol, Baltimore, MD USA

[15] Univ Texas Austin, Dell Med Sch, Dept Neurol, Austin, TX 78712 USA

[16] Yale Univ, Dept Neurol, New Haven, CT USA

[17] Univ Toronto, St Michaels Hosp, Div Neurol, Toronto, ON, Canada

[18] Univ Texas, Hlth Sci Ctr, Dept Neurol, Houston, TX USA

[19] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA USA

[20] Univ Vermont, Larner Coll Med, Dept Neurol Sci, Burlington, VT USA

[21] Univ Penn, Ctr Biomed Image Comp & Analyt, Perelman Sch Med, Philadelphia, PA USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2024年 / 30卷 / 10期

基金：

美国国家卫生研究院;

关键词：

biomarker; central vein sign; diagnostic imaging; multiple sclerosis; oligoclonal bands; MISDIAGNOSIS; LESIONS;

D O I：

10.1177/13524585241271988

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Cerebrospinal fluid (CSF) oligoclonal bands (OCB) are a diagnostic biomarker in multiple sclerosis (MS). The central vein sign (CVS) is an imaging biomarker for MS that may improve diagnostic accuracy. Objectives: The objective of the study is to examine the diagnostic performance of simplified CVS methods in comparison to OCB in participants with clinical or radiological suspicion for MS. Methods: Participants from the CentrAl Vein Sign in MS (CAVS-MS) pilot study with CSF testing were included. Select-3 and Select-6 (counting up to three or six CVS+ lesions per scan) were rated on post-gadolinium FLAIR* images. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value for Select-3, Select-6, OCB, and combinations thereof were calculated for MS diagnosis at baseline and at 12 months. Results: Of 53 participants, 25 were OCB+. At baseline, sensitivity for MS diagnosis was 0.75 for OCB, 0.83 for Select-3, and 0.71 for Select-6. Specificity for MS diagnosis was 0.76 for OCB, 0.48 for Select-3, and 0.86 for Select-6. At 12 months, PPV for MS diagnosis was 0.95 for Select-6 and 1.00 for Select-6 with OCB+ status. Discussion: Results suggest similar diagnostic performance of simplified CVS methods and OCB. Ongoing studies will refine whether CVS could be used in replacement or in conjunction with OCB.

引用

页码：1239 / +

页数：147

共 35 条

[1] Lesion size and shape in central vein sign assessment for multiple sclerosis diagnosis: An in vivo and postmortem MRI study [J].

Al-Louzi, Omar ;

Manukyan, Sargis ;

Donadieu, Maxime ;

Absinta, Martina ;

Letchuman, Vijay ;

Calabresi, Brent ;

Desai, Parth ;

Beck, Erin S. ;

Roy, Snehashis ;

Ohayon, Joan ;

Pham, Dzung L. ;

Thomas, Anish ;

Jacobson, Steven ;

Cortese, Irene ;

Auluck, Pavan K. ;

Nair, Govind ;

Sati, Pascal ;

Reich, Daniel S. .

MULTIPLE SCLEROSIS JOURNAL, 2022, 28 (12) :1891-1902

[2] The Economic Burden of Multiple Sclerosis in the United States Estimate of Direct and Indirect Costs [J].

Bebo, Bruce ;

Cintina, Inna ;

LaRocca, Nicholas ;

Ritter, Leslie ;

Talente, Bari ;

Hartung, Daniel ;

Ngorsuraches, Surachat ;

Wallin, Mitchell ;

Yang, Grace .

NEUROLOGY, 2022, 98 (18) :E1810-E1817

[3] Central vein sign for multiple sclerosis: A systematic review and meta-analysis [J].

Bhandari, A. ;

Xiang, H. ;

Lechner-Scott, J. ;

Agzarian, M. .

CLINICAL RADIOLOGY, 2020, 75 (06) :479.e9-479.e15

[4] The Use of the Central Vein Sign in the Diagnosis of Multiple Sclerosis: A Systematic Review and Meta-analysis [J].

Castellaro, Marco ;

Tamanti, Agnese ;

Pisani, Anna Isabella ;

Pizzini, Francesca Benedetta ;

Crescenzo, Francesco ;

Calabrese, Massimiliano .

DIAGNOSTICS, 2020, 10 (12)

[5] Value of 3T Susceptibility-Weighted Imaging in the Diagnosis of Multiple Sclerosis [J].

Clarke, M. A. ;

Pareto, D. ;

Pessini-Ferreira, L. ;

Arrambide, G. ;

Alberich, M. ;

Crescenzo, F. ;

Cappelle, S. ;

Tintore, M. ;

Sastre-Garriga, J. ;

Auger, C. ;

Montalban, X. ;

Evangelou, N. ;

Rovira, A. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2020, 41 (06) :1001-1008

[6] Value of the central vein sign at 3T to differentiate MS from seropositive NMOSD [J].

Cortese, Rosa ;

Magnollay, Lise ;

Tur, Carmen ;

Abdel-Aziz, Khaled ;

Jacob, Anu ;

De Angelis, Floriana ;

Yiannakas, Marios C. ;

Prados, Ferran ;

Ourselin, Sebastien ;

Yousry, Tarek A. ;

Barkhof, Frederik ;

Ciccarelli, Olga .

NEUROLOGY, 2018, 90 (14) :E1183-+

[7] A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis [J].

Daboul, Lynn ;

O'Donnell, Carly M. ;

Amin, Moein ;

Rodrigues, Paulo ;

Derbyshire, John ;

Azevedo, Christina ;

Bar-Or, Amit ;

Caverzasi, Eduardo ;

Calabresi, Peter A. ;

Cree, Bruce A. C. ;

Freeman, Leorah ;

Henry, Roland G. ;

Longbrake, Erin E. ;

Oh, Jiwon ;

Papinutto, Nico ;

Pelletier, Daniel ;

Prchkovska, Vesna ;

Raza, Praneeta ;

Ramos, Marc ;

Samudralwar, Rohini D. ;

Schindler, Matthew K. ;

Sotirchos, Elias S. ;

Sicotte, Nancy L. ;

Solomon, Andrew J. ;

Shinohara, Russell T. ;

Reich, Daniel S. ;

Sati, Pascal ;

Ontaneda, Daniel .

MULTIPLE SCLEROSIS JOURNAL, 2024, 30 (01) :25-34

[8] Effect of GBCA Use on Detection and Diagnostic Performance of the Central Vein Sign: Evaluation Using a 3-T FLAIR* Sequence in Patients With Suspected Multiple Sclerosis [J].

Daboul, Lynn ;

O'Donnell, Carly M. ;

Cao, Quy ;

Amin, Moein ;

Rodrigues, Paulo ;

Derbyshire, John ;

Azevedo, Christina ;

Bar-Or, Amit ;

Caverzasi, Eduardo ;

Calabresi, Peter ;

Cree, Bruce A. C. ;

Freeman, Leorah ;

Henry, Roland G. ;

Longbrake, Erin E. ;

Nakamura, Kunio ;

Oh, Jiwon ;

Papinutto, Nico ;

Pelletier, Daniel ;

Samudralwar, Rohini D. ;

Suthiphosuwan, Suradech ;

Schindler, Matthew K. ;

Sotirchos, Elias S. ;

Sicotte, Nancy L. ;

Solomon, Andrew J. ;

Shinohara, Russell T. ;

Reich, Daniel S. ;

Ontaneda, Daniel ;

Sati, Pascal .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2023, 220 (01) :115-125

[9] Automated Integration of Multimodal MRI for the Probabilistic Detection of the Central Vein Sign in White Matter Lesions [J].

Dworkin, J. D. ;

Sati, P. ;

Solomon, A. ;

Pham, D. L. ;

Watts, R. ;

Martin, M. L. ;

Ontaneda, D. ;

Schindler, M. K. ;

Reich, D. S. ;

Shinohara, R. T. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2018, 39 (10) :1806-1813

[10] Complications of lumbar puncture [J].

Evans, RW .

NEUROLOGIC CLINICS, 1998, 16 (01) :83-+

← 1 2 3 4 →