Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents

被引：2

作者：

Andreeva, Tonya D. ^{[1
,2
]}

Walker, Oliver ^{[1
]}

Rudt, Alexander ^{[1
]}

Jung, Ole ^{[3
]}

Barbeck, Mike ^{[3
]}

Guelcher, Manfred ^{[4
,5
]}

Krastev, Rumen ^{[1
,6
]}

机构：

[1] Reutlingen Univ, Fac Life Sci, Alteburgstr 150, D-72762 Reutlingen, Germany

[2] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Acad G Bonchev Str 21, Sofia 1113, Bulgaria

[3] Univ Med Ctr Rostock, Clin & Policlin Dermatol & Venereol, Strempelstr 13, D-18057 Rostock, Germany

[4] QualiMed Innovat Med Prod GmbH, D-21423 Winsen, Germany

[5] Subsidiary Q3 Med Devices, Dublin, Ireland

[6] Univ Tubingen, NMI Nat & Med Sci Inst, Dept Mat Dev & Functionalizat, D-72770 Reutlingen, Germany

来源：

HELIYON | 2024年 / 10卷 / 13期

关键词：

Magnesium alloy; Mg -based stents; Corrosion resistance; In -vitro degradation; Composite coatings; IN-VITRO DEGRADATION; POLYELECTROLYTE MULTILAYERS; ALLOY; DEPOSITION; FILMS; PERMEABILITY; RESISTANCE; VIABILITY; ADHESION; CELLS;

D O I：

10.1016/j.heliyon.2024.e34025

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Magnesium and its alloys are suitable materials for biodegradable biomedical implants such as cardiovascular stents. Here we introduce an innovative composite polyelectrolyte multilayer/wax coating applied to commercial coronary Mg-based stents serving as a barrier layer effectively retarding corrosion. This hydrophobic coating, build by layer-by-layer technology, appeared very thin, smooth, homogeneous, strongly adherent and completely covering the surface of the Mgstent. In-vitro degradation tests showed greater resistance to degradation of coated Mg-stents compared to uncoated and passivated ones. Cytocompatibility studies proved that Mg-stent coated with the composite coating was non-cytotoxic and improved fibroblast cell viability compared to the uncoated Mg-stent.

引用

页数：13

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