Intermolecular Formal [2π+2σ] Cycloaddition of Enol Silyl Ethers with Bicyclo[1.1.0]butanes Promoted by Lewis Acids

被引：7
|
作者：
Zhu, Shijie [1 ]
Tian, Xue [1 ]
Li, Shi-Wu [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Xinjiang, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 30期
基金：
中国国家自然科学基金;
关键词：
STRAIN-RELEASE; CHEMISTRY;
D O I：
10.1021/acs.orglett.4c01512
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Silyl enol ethers react with bicyclo[1.1.0]butanes (BCBs) through Yb(OTf)(3)-promoted formal [2 pi + 2 sigma] cycloaddition reactions to furnish bicyclo[2.1.1]hexanes (BCHs). This new reaction tolerated a wide range of enol silyl ethers and BCBs. Furthermore, the amplification experiments and synthetic transformations of the cycloaddition compounds further highlighted their practicality.
引用
收藏
页码：6309 / 6313
页数：5
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