Molecular Profile as an Outcome Predictor in Glioblastoma along with MRI Features and Surgical Resection: A Scoping Review

被引:4
作者
Papacocea, Serban Iancu [1 ]
Vrinceanu, Daniela [2 ]
Dumitru, Mihai [2 ]
Manole, Felicia [3 ]
Serboiu, Crenguta [4 ]
Papacocea, Marius Toma [1 ]
机构
[1] Carol Davila Univ Med & Pharm, Neurosurg Dept, Bucharest 020021, Romania
[2] Carol Davila Univ Med & Pharm, ENT Dept, Bucharest 020021, Romania
[3] Univ Oradea, Fac Med, ENT Dept, Oradea 410073, Romania
[4] Carol Davila Univ Med & Pharm, Cellular Biol & Histol Dept, Bucharest 020021, Romania
关键词
GBM; molecular; predictor; outcome; surgery; MGMT PROMOTER METHYLATION; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR RECEPTOR; TERT PROMOTER; PROGNOSTIC VALUE; MALIGNANT GLIOMA; IDH1; MUTATIONS; PHASE-II; TEMOZOLOMIDE; SURVIVAL;
D O I
10.3390/ijms25179714
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glioblastoma (GBM) is one of the most aggressive malignant tumors of the brain. We queried PubMed for articles about molecular predictor markers in GBM. This scoping review aims to analyze the most important outcome predictors in patients with GBM and to compare these factors in terms of absolute months of survival benefit and percentages. Performing a gross total resection for patients with GBM undergoing optimal chemo- and radiotherapy provides a significant benefit in overall survival compared to those patients who received a subtotal or partial resection. However, compared to IDH-Wildtype GBMs, patients with IDH-Mutant 1/2 GBMs have an increased survival. MGMT promoter methylation status is another strong outcome predictor for patients with GBM. In the reviewed literature, patients with methylated MGMT promoter lived approximately 50% to 90% longer than those with an unmethylated MGMT gene promoter. Moreover, KPS is an important predictor of survival and quality of life, demonstrating that we should refrain from aggressive surgery in important brain areas. As new therapies (such as TTFs) emerge, we are optimistic that the overall median survival will increase, even for IDH-Wildtype GBMs. In conclusion, molecular profiles are stronger outcome predictors than the extent of neurosurgical resection for GBM.
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页数:19
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