Glioblastoma (GBM) is one of the most aggressive malignant tumors of the brain. We queried PubMed for articles about molecular predictor markers in GBM. This scoping review aims to analyze the most important outcome predictors in patients with GBM and to compare these factors in terms of absolute months of survival benefit and percentages. Performing a gross total resection for patients with GBM undergoing optimal chemo- and radiotherapy provides a significant benefit in overall survival compared to those patients who received a subtotal or partial resection. However, compared to IDH-Wildtype GBMs, patients with IDH-Mutant 1/2 GBMs have an increased survival. MGMT promoter methylation status is another strong outcome predictor for patients with GBM. In the reviewed literature, patients with methylated MGMT promoter lived approximately 50% to 90% longer than those with an unmethylated MGMT gene promoter. Moreover, KPS is an important predictor of survival and quality of life, demonstrating that we should refrain from aggressive surgery in important brain areas. As new therapies (such as TTFs) emerge, we are optimistic that the overall median survival will increase, even for IDH-Wildtype GBMs. In conclusion, molecular profiles are stronger outcome predictors than the extent of neurosurgical resection for GBM.
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Wu, Zhen
Zhang, Junting
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机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Zhang, Junting
Zhang, Liwei
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h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Zhang, Liwei
Jia, Guijun
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Jia, Guijun
Tang, Jie
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Tang, Jie
Wang, Liang
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h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Wang, Liang
Wang, Zhongcheng
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h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Xu, Cuiping
Yu, Tao
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Yu, Tao
Zhang, Guojun
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Zhang, Guojun
Rajah, Gary B.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USACapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Rajah, Gary B.
Wang, Yuping
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Wang, Yuping
Li, Yongjie
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
机构:
Omi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan
Shiga Univ Med Sci, Dept Neurosurg, Otsu, JapanOmi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan
Nakasu, Satoshi
Deguchi, Shoichi
论文数: 0引用数: 0
h-index: 0
机构:
Shizuoka Canc Ctr, Div Neurosurg, Nagaizumi, JapanOmi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan
Deguchi, Shoichi
Nakasu, Yoko
论文数: 0引用数: 0
h-index: 0
机构:
Shiga Univ Med Sci, Dept Neurosurg, Otsu, Japan
Shizuoka Canc Ctr, Div Neurosurg, Nagaizumi, JapanOmi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Wu, Zhen
Zhang, Junting
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Zhang, Junting
Zhang, Liwei
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Zhang, Liwei
Jia, Guijun
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Jia, Guijun
Tang, Jie
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Tang, Jie
Wang, Liang
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
Wang, Liang
Wang, Zhongcheng
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Skull Base & Brainstem Tumor Div, Dept Neurosurg, Beijing 100050, Peoples R China
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Xu, Cuiping
Yu, Tao
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Yu, Tao
Zhang, Guojun
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Zhang, Guojun
Rajah, Gary B.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USACapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Rajah, Gary B.
Wang, Yuping
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Wang, Yuping
Li, Yongjie
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
Beijing Inst Funct Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
机构:
Omi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan
Shiga Univ Med Sci, Dept Neurosurg, Otsu, JapanOmi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan
Nakasu, Satoshi
Deguchi, Shoichi
论文数: 0引用数: 0
h-index: 0
机构:
Shizuoka Canc Ctr, Div Neurosurg, Nagaizumi, JapanOmi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan
Deguchi, Shoichi
Nakasu, Yoko
论文数: 0引用数: 0
h-index: 0
机构:
Shiga Univ Med Sci, Dept Neurosurg, Otsu, Japan
Shizuoka Canc Ctr, Div Neurosurg, Nagaizumi, JapanOmi Med Ctr, Div Neurosurg, Yabase Cho 1660, Kusatsu, Shiga 5258585, Japan